YRC Public Data Repository - Protein Structure Prediction

Protein:	DXR_ECOLI
Organism:	Escherichia coli
Length:	398 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DXR_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|81239711, gi\|... - gi\|82775563\|ref\|YP_401910.1\| 1-deoxy-D-xylulose 5-phosphate reductoisomerase [Shigella dysenteriae S...	539.0	[0..1]	[398..1]
DXR_PHOLL - 1-deoxy-D-xylulose 5-phosphate reductoisomerase OS=Photorhabdus luminescens subsp. laumondii GN=dxr ... DXR_PHOLL - 1-deoxy-D-xylulose 5-phosphate reductoisomerase OS=Photorhabdus luminescens subsp. laumondii (strain...	539.0	[0..1]	[396..1]
DXR_PASMU - 1-deoxy-D-xylulose 5-phosphate reductoisomerase OS=Pasteurella multocida GN=dxr PE=3 SV=1 DXR_PASMU - 1-deoxy-D-xylulose 5-phosphate reductoisomerase OS=Pasteurella multocida (strain Pm70) GN=dxr PE=3 S...	531.0	[0..1]	[397..7]
DXR_ARATH - 1-deoxy-D-xylulose 5-phosphate reductoisomerase, chloroplastic OS=Arabidopsis thaliana GN=DXR PE=2 S...	531.0	[0..2]	[392..81]
gi\|9800656 - gi\|9800656\|gb\|AAD56391.2\|AF182287_1 1-deoxy-D-xylulose-5-phosphate reductoisomerase [Artemisia annua...	531.0	[0..2]	[392..75]
DXR_ERWCT - 1-deoxy-D-xylulose 5-phosphate reductoisomerase OS=Erwinia carotovora subsp. atroseptica GN=dxr PE=3... DXR_PECAS - 1-deoxy-D-xylulose 5-phosphate reductoisomerase OS=Pectobacterium atrosepticum (strain SCRI 1043 / A...	530.0	[0..1]	[393..1]
gi\|87299431 - gi\|87299431\|dbj\|BAE79548.1\| 1-deoxyxylulose 5-phosphate reductoisomerase [Chrysanthemum x morifolium...	530.0	[0..2]	[388..75]
DXR_NITEC - 1-deoxy-D-xylulose 5-phosphate reductoisomerase OS=Nitrosomonas eutropha (strain C91) GN=dxr PE=3 SV...	530.0	[0..2]	[397..5]
DXR_ORYSA - 1-deoxy-D-xylulose 5-phosphate reductoisomerase, chloroplast precursor (EC 1.1.1.267) (DXP reductois... DXR_ORYSJ - 1-deoxy-D-xylulose 5-phosphate reductoisomerase, chloroplastic OS=Oryza sativa subsp. japonica GN=DX...	529.0	[0..2]	[392..77]
gi\|17225989 - gi\|17225989\|gb\|AAL37560.1\|AF367205_1 1-deoxy-D-xylulose 5-phosphate reductoisomerase precursor [Oryz...	529.0	[0..2]	[392..77]

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Predicted Domain #1

Region A:
Residues: [1-398]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKQLTILGST GSIGCSTLDV VRHNPEHFRV VALVAGKNVT RMVEQCLEFS PRYAVMDDEA  60
   61 SAKLLKTMLQ QQGSRTEVLS GQQAACDMAA LEDVDQVMAA IVGAAGLLPT LAAIRAGKTI 120
  121 LLANKESLVT CGRLFMDAVK QSKAQLLPVD SEHNAIFQSL PQPIQHNLGY ADLEQNGVVS 180
  181 ILLTGSGGPF RETPLRDLAT MTPDQACRHP NWSMGRKISV DSATMMNKGL EYIEARWLFN 240
  241 ASASQMEVLI HPQSVIHSMV RYQDGSVLAQ LGEPDMRTPI AHTMAWPNRV NSGVKPLDFC 300
  301 KLSALTFAAP DYDRYPCLKL AMEAFEQGQA ATTALNAANE ITVAAFLAQQ IRFTDIAALN 360
  361 LSVLEKMDMR EPQCVDDVLS VDANAREVAR KEVMRLAS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	149.0
Match:	1q0hA
Description:	Crystal structure of selenomethionine-labelled DXR in complex with fosmidomycin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
1-deoxy-D-xylulose-5-phosphate reductoisomerase activity	3.73695658845135	bayes_pls_golite062009
glucose-6-phosphate dehydrogenase activity	2.40527964325542	bayes_pls_golite062009
catalytic activity	1.79741889688267	bayes_pls_golite062009
oxidoreductase activity	1.69771604880532	bayes_pls_golite062009
glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity	1.08771562641109	bayes_pls_golite062009
retinol dehydrogenase activity	1.07588236908906	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	0.418775403210681	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	0.32207755075663	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: