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View Structure Prediction Details

Protein: pita-PB
Organism: Drosophila melanogaster
Length: 623 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for pita-PB.

Description E-value Query
Range
Subject
Range
gi|76678552 - gi|76678552|ref|XP_583095.2| PREDICTED: similar to Zinc finger protein 268 (Zinc finger protein HZF3...
769.0 [0..2] [623..612]

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Predicted Domain #1
Region A:
Residues: [1-68]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPGHICLECR LLFEHCYRFK QMCKRAETLL RQYPLTGNWP SPLEKPRAPM TMVASKKLLV  60
   61 VPAKTAEP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [69-132]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SETPKKLLNT MAKSSSQVII EDVQVLESAM VTPRTVAGSS PVPRRSHAYE LKVDNNQELS  60
   61 MDDV

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [133-376]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QSMLEDMASE LEKEFPDIPQ KASPVKPKVL NKSSIRILNK GPAAPVEPRL ATPKVKRDDS  60
   61 GNVAIVTEVL DSDLPLDDQD DPTKNAEKVA TDVFPCPDCE RSFPLQQLLE IHRLNHTRSR 120
  121 SFQCLLCEKS FFSKYDLAKH NFVHTGERPF KCAICSKAFT RKALLHRHER THTDVPKFIC 180
  181 VYCEKPFLSR QEMEKHAERH QKKRPFQCGV CTKSFAFKQG LERHETVHST NLPFPCQHCE 240
  241 RSFS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 62.221849
Match: 2i13A
Description: No description for 2i13A was found.

Predicted Domain #4
Region A:
Residues: [377-434]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TASKLARHLV AHAGKRAYPC KYCHKSYMLS HHLSRHLRTH TQTSDASFVC SECKVSYS

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 4.78
Match: 1g2fC
Description: TATA box-binding zinc finger, TATAZF
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [435-568]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NYNDLLDHAL IHATASLKCP MCRKQIEDID SVESHMDQHK QSERHACEFC DHIFLTQKCL  60
   61 QRHIEDDHVV EMEPYQNEFE DDGEGEGGVD EKEEHLDDFE DMDNVKQEEF VTEYLEDDAL 120
  121 YEDHLDDSDE SFTP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 20.154902
Match: 1tf6A
Description: Transcription factor IIIA, TFIIIA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.70988788192472 bayes_pls_golite062009
nucleic acid binding 4.58713908116892 bayes_pls_golite062009
DNA binding 4.56219307357342 bayes_pls_golite062009
transcription factor activity 3.50954949535763 bayes_pls_golite062009
transcription repressor activity 3.27542149084008 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.22082323675675 bayes_pls_golite062009
binding 3.10743787485868 bayes_pls_golite062009
transcription activator activity 2.19952417915035 bayes_pls_golite062009
chromatin binding 2.18464662431232 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.63161912031789 bayes_pls_golite062009
structure-specific DNA binding 1.48624530884061 bayes_pls_golite062009
sequence-specific DNA binding 1.42975942698743 bayes_pls_golite062009
transcription factor binding 1.39608963544799 bayes_pls_golite062009
transcription corepressor activity 1.34049786451995 bayes_pls_golite062009
double-stranded DNA binding 1.18599503594288 bayes_pls_golite062009
protein binding 1.00484935878505 bayes_pls_golite062009
transcription cofactor activity 0.77874411480713 bayes_pls_golite062009
cytoskeletal protein binding 0.311339098303136 bayes_pls_golite062009
catalytic activity 0.245893663605433 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [569-623]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPPKQRKTNP PKDAQQSVRQ TRSRDAQRIT QKTGKNEGKP HHKLERNLKN RRSAK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 20.39794
Match: 1ubdC
Description: Ying-yang 1 (yy1, zinc finger domain)
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle