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View Structure Prediction Details

Protein: Dyb-PC
Organism: Drosophila melanogaster
Length: 623 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Dyb-PC.

Description E-value Query
Range		 Subject
Range
DTNB_RAT - Dystrobrevin beta OS=Rattus norvegicus GN=Dtnb PE=1 SV=2
 514.0 [0..1] [604..1]

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Predicted Domain #1
Region A:
Residues: [1-250] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLEVVFGRGM ELEPRVAILQ DLRLQTFDSI RFASYRTASK LRYIQKSTNL HLVDIWNVIE  60
   61 AFRENGLNTL EPQSEVSVAR LETLVSSLYH NLNKRLPTAQ QVPVDSKAGL LLNWLLAAYT 120
  121 SDNSGKIRVF SIKVALATMC SGKLVDKLRY IFSQISDGAG QLVAWKLGEF LREVLALPAA 180
  181 VYESPTFHYK EGLEEEIFPA ENKVTVNDFM ATLMSEPGPS CLVWLPLVHR LATVETIVHP 240
  241 TVCSVCHKEN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 85.154902
Match: 1eg3A
Description: Dystrophin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
structural constituent of muscle 5.54109779906915 bayes_pls_golite062009
acetylcholine transmembrane transporter activity 4.63361193364389 bayes_pls_golite062009
transcription regulator activity 3.2682543222543 bayes_pls_golite062009
binding 2.62219069341981 bayes_pls_golite062009
transcription activator activity 2.28375305944516 bayes_pls_golite062009
transcription factor binding 2.18630749239417 bayes_pls_golite062009
cytoskeletal protein binding 2.11906774871731 bayes_pls_golite062009
metal ion binding 2.11094352721028 bayes_pls_golite062009
cation binding 2.11094352721028 bayes_pls_golite062009
ion binding 2.10331783734535 bayes_pls_golite062009
transcription cofactor activity 2.07432061489599 bayes_pls_golite062009
transcription coactivator activity 2.02433252968502 bayes_pls_golite062009
actin binding 2.02356543483094 bayes_pls_golite062009
DNA binding 1.73924929536227 bayes_pls_golite062009
nucleic acid binding 1.53225451586959 bayes_pls_golite062009
protein binding 1.46903005775608 bayes_pls_golite062009
calcium ion binding 1.40919295397643 bayes_pls_golite062009
myosin binding 1.23881879879813 bayes_pls_golite062009
transporter activity 1.15928534291452 bayes_pls_golite062009
motor activity 1.08123526270094 bayes_pls_golite062009
nitric-oxide synthase binding 0.965098383344279 bayes_pls_golite062009
transmembrane transporter activity 0.945691505472547 bayes_pls_golite062009
molecular transducer activity 0.933783050059916 bayes_pls_golite062009
signal transducer activity 0.933783050059916 bayes_pls_golite062009
microfilament motor activity 0.867600046278719 bayes_pls_golite062009
amine transmembrane transporter activity 0.717054504236607 bayes_pls_golite062009
substrate-specific transporter activity 0.693724160233023 bayes_pls_golite062009
structural molecule activity 0.640474644163009 bayes_pls_golite062009
actin filament binding 0.512173584028638 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.45412801027969 bayes_pls_golite062009
myosin II heavy chain binding 0.308481284245779 bayes_pls_golite062009
active transmembrane transporter activity 0.246383459363256 bayes_pls_golite062009
catalytic activity 0.210712504691113 bayes_pls_golite062009
actin-dependent ATPase activity 0.205877568518 bayes_pls_golite062009
ion transmembrane transporter activity 0.193201281459889 bayes_pls_golite062009
transcription repressor activity 0.18603158355229 bayes_pls_golite062009
myosin heavy chain binding 0.15875878144391 bayes_pls_golite062009
cation transmembrane transporter activity 0.0305250212662123 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [251-282] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FTGFRYRCQR CHAYQLCQEC FWHGKTSLNH QN

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.08
Match: 2e5rA
Description: No description for 2e5rA was found.

Predicted Domain #3
Region A:
Residues: [283-623] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DHEVKEYSSY KSPSKQIGHS LRKSFRCVPE KTVQVLPRFP DQPEKTLNLS HIVPPSPLPS  60
   61 HNGFSDPSGL VHGHHGPHPG LPGQHGLFDR SSTLDSRATG RSLDSASGTA GTTMSRVAAA 120
  121 SANDEEHRLI ARYAARLAQE NRAPSNLPDN ATPIGTDNSR AQRELIAQLE SKNKEIMREI 180
  181 ARLRRQQETE QMAPENPALI NELRALRQRK GELEGHLGAL QDSRRQLMEQ LEGLMRMLKN 240
  241 QQTASPRSTP NSSPRSGKSP PMPGGAGILG TSPMSALHAQ QMQQHPMAGG VRASQQQLLQ 300
  301 QQQQQAHGHG PFSQSQLEQL NQISSDMRSA FAANGSASKC E

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 9.522879
Match: 2dfsA
Description: No description for 2dfsA was found.
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle