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Protein Overview: HEM3

General Information:
Name(s) found: HEM3 / YDL205C [SGD]
Description(s) found:
Found 31 descriptions.
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  • Porphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 327 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: heme biosynthetic process [IMPLink to PubMed article]
    Molecular Function: hydroxymethylbilane synthase activity [IEPLink to PubMed article][IMPLink to PubMed articleLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGPETLHIGG RKSKLAVIQS NHVLKLIEEK YPDYDCKVFT LQTLGDQIQF KPLYSFGGKA  60
   61 LWTKELEDHL YHDDPSKKLD LIVHSLKDMP TLLPEGFELG GITKRVDPTD CLVMPFYSAY 120
  121 KSLDDLPDGG IVGTSSVRRS AQLKRKYPHL KFESVRGNIQ TRLQKLDDPK SPYQCIILAS 180
  181 AGLMRMGLEN RITQRFHSDT MYHAVGQGAL GIEIRKGDTK MMKILDEICD LNATICCLSE 240
  241 RALMRTLEGG CSVPIGVESK YNEETKKLLL KAIVVDVEGT EAVEDEIEML IENVKEDSMA 300
  301 CGKILAERMI ADGAKKILDE INLDRIK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data HEM3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..104]
    [209..231]    		 PSI-BLAST 596.9897 Porphobilinogen deaminase (hydroxymethylbilane synthase), N-terminal domain; Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain
    2 View Details [105..208]
    [232..327]    		 PSI-BLAST 596.9897 Porphobilinogen deaminase (hydroxymethylbilane synthase), N-terminal domain; Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle