Protein Overview: SRP102

General Information:
Name(s) found:	SRP102 / YKL154W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6322695\|ref\|NP_012768.1\| Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors Srp101p to the ER membrane; Srp102p [Saccharomyces cerevisiae] [NCBI NR] gi\|549728\|sp\|P36057.1\|SRPB_YEAST RecName: Full=Signal recognition particle receptor subunit beta; Short=SR-beta [NCBI NR] pir\|\|S37984 probable purine nucleotide-binding protein YKL154w - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|486267\|emb\|CAA81995.1\| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR] Signal recognition particle receptor subunit beta OS=Saccharomyces cerevisiae GN=SRP102 PE=1 SV=1 [Swiss-Prot] SRP102 Signal recognition particle receptor, beta chain [mips] Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors Srp101p to the ER membrane [SGD] SRP102, Chr XI from 161603-162337 [yeast_orfs2] Chr XI from 161603-162337 [yeastorf3.fasta] Chr XI from 161602-162336 [yeastorf4.fasta] (P36057) Signal recognition particle receptor beta subunit (SR-beta) [4932.FASTACCERV.txt] SRP102 SGDID:S0001637, Chr XI from 161606-162340, Verified ORF [yeastflysequest.fasta] Signal recognition particle receptor beta subunit [Saccharomyces cerevisiae]gi\|486267\|emb\|CAA81995.1\| unnamed protein product [Saccharomyces cerevisiae]gi\|539328\|pir\|\|S37984 probable purine nucleotide-binding protein YKL154w - yeast (Saccharomyces cere [nrdb_11152004_Chlamydomonas] SRP102 SGDID:S000001637, Chr XI from 161606-162340, Verified ORF, "Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors Srp101p to the ER membrane" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors Srp101p to the ER membrane; Srp102p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Signal recognition particle receptor subunit beta (SR-beta) [nr-271106-contam.fasta] [chemostatdb.fasta] Signal recognition particle receptor subunit beta OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SRP102 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] SRP102 SGDID:S000001637, Chr XI from 161601-162335, Genome Release 64-1-1, Verified ORF, "Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors the alpha subunit, Srp101p to the ER membrane" [yeast-030211-contam.fasta] SRP102 SGDID:S000001637, Chr XI from 161601-162335, Genome Release 64-2-1, Verified ORF, "Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors the alpha subunit, Srp101p to the ER membrane" [20141208_orf_trans.fasta] YKL154W SGDID:S000001637, Chr XI from 161601-162335, Genome Release 64-1-1, Verified ORF, "Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors the alpha subunit, Srp101p to the ER membrane" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	244 amino acids
Gene Ontology:
Cellular Component:	integral to endoplasmic reticulum membrane [IDA] signal recognition particle receptor complex [TAS]
Biological Process:	SRP-dependent cotranslational protein targeting to membrane [IC][TAS] protein targeting to ER [IMP]
Molecular Function:	GTP binding [IPI] GTPase activity [ISS] signal recognition particle binding [IMP][IPI][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSNTLIIAC LLVIGTTIAL IAVQKASSKT GIKQKSYQPS IIIAGPQNSG KTSLLTLLTT  60
   61 DSVRPTVVSQ EPLSAADYDG SGVTLVDFPG HVKLRYKLSD YLKTRAKFVK GLIFMVDSTV 120
  121 DPKKLTTTAE FLVDILSITE SSCENGIDIL IACNKSELFT ARPPSKIKDA LESEIQKVIE 180
  181 RRKKSLNEVE RKINEEDYAE NTLDVLQSTD GFKFANLEAS VVAFEGSINK RKISQWREWI 240
  241 DEKL

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		SRP101 SRP102
View Details	(MIPS) Mewes HW, et al. (2004)		SRP101 SRP102
View Details	Gavin AC, et al. (2006)		SRP101 SRP102
View Details	Gavin AC, et al. (2002)		SRP101 SRP102
View Details	Qiu et al. (2008)		MLP1 MLP2 SBH1 SBH2 SEC11 SEC59 SEC62 SEC66 SRP101 SRP102 SSH1 SSS1

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	PRP42	SRP102	1	Unpublished Fields Lab Data
View Screen	SCL1	SRP102	1	Unpublished Fields Lab Data
View Screen	TWF1	SRP102	1	Unpublished Fields Lab Data
View Screen	YCK1	SRP102	1	Unpublished Fields Lab Data
View Screen	UBC7	SRP102	1	Unpublished Fields Lab Data
View Screen	YOL014W	SRP102	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	SRP102	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..244]	PSI-BLAST	92.035458	ADP-ribosylation factor

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
signal recognition particle binding	5.12760449152779	bayes_pls_golite062009
ribonucleoprotein binding	3.19511216911452	bayes_pls_golite062009
transporter activity	3.10463051760206	bayes_pls_golite062009
transmembrane transporter activity	2.95886887664984	bayes_pls_golite062009
nucleoside-triphosphatase activity	2.95079405147356	bayes_pls_golite062009
pyrophosphatase activity	2.87427509025394	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	2.85499564954033	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	2.85178667290149	bayes_pls_golite062009
primary active transmembrane transporter activity	2.61775212528604	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	2.61467977505707	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	2.57552435627908	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	2.57107347424517	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	2.57054427875021	bayes_pls_golite062009
active transmembrane transporter activity	2.50494515048649	bayes_pls_golite062009
ATPase activity, coupled	2.43862163407966	bayes_pls_golite062009
ATPase activity	2.39535714892224	bayes_pls_golite062009
substrate-specific transporter activity	1.91091452720653	bayes_pls_golite062009
binding	1.77927104644254	bayes_pls_golite062009
protein transporter activity	1.71214667007262	bayes_pls_golite062009
hydrolase activity	1.57549510726226	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.56325751172863	bayes_pls_golite062009
ion transmembrane transporter activity	0.977237423302079	bayes_pls_golite062009
purine nucleotide binding	0.929901285538132	bayes_pls_golite062009
nucleotide binding	0.922442819194247	bayes_pls_golite062009
purine ribonucleotide binding	0.920987930180051	bayes_pls_golite062009
ribonucleotide binding	0.920926158369519	bayes_pls_golite062009
motor activity	0.87979065815418	bayes_pls_golite062009
guanyl nucleotide binding	0.640772201693186	bayes_pls_golite062009
guanyl ribonucleotide binding	0.63468044350616	bayes_pls_golite062009
GTP binding	0.621689261700018	bayes_pls_golite062009
cation transmembrane transporter activity	0.557919489256916	bayes_pls_golite062009
GTPase activity	0.437665353870877	bayes_pls_golite062009
ATP binding	0.41092997612902	bayes_pls_golite062009
adenyl ribonucleotide binding	0.385813421701492	bayes_pls_golite062009
adenyl nucleotide binding	0.377870145186619	bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism	0.213018989352421	bayes_pls_golite062009
protein binding	0.193768631623192	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	0.123304946374679	bayes_pls_golite062009
metal ion transmembrane transporter activity	0.0775601177068852	bayes_pls_golite062009

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2