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Protein Overview: SEC59

General Information:
Name(s) found: SEC59 / YMR013C [SGD]
Description(s) found:
Found 30 descriptions.
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  • Dolichol kinase, catalyzes the terminal step in dolichyl monophosphate (Dol-P) biosynthesis; required for viability and for normal rates of lipid intermediate synthesis and protein N-glycosylation [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 519 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum membrane [IDALink to PubMed article][IMPLink to PubMed article]
    Biological Process: protein amino acid glycosylation [IMPLink to PubMed article]
    protein targeting to ER [IMPLink to PubMed article]
    Molecular Function: dolichol kinase activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVAIIPHASF TTIKLTQKTE GSQMPTEEIC KINMRTRKFD VGGNSRDFEC FYSNFVQTVI  60
   61 LLGTFFYCVE RLQPWSIVTA DISYKQIFVN VFVVCLIMVG LIFTKYWQHG YKSLPKFDTI 120
  121 YSLYLPFMVS LLFDTSSTVI NTILILSVLN SYRWRTQLVV IILQLCLIFF NFEAGDRLKN 180
  181 IISIVINSLL SLILKYIGQL KSLDNIDSNL FSILLTNILY VSEAGTVHFR ILKGIILALT 240
  241 TIISINYVLK KVMHFKPFML SISFAIGLPL FANTFIHLED GENPLLWLVK YILESTIRQK 300
  301 ILFAWSSILI LSIPSILIEK DSLSLNTSRK LWHFIIFLLI IPSFQMDSNF VKIALSGTIP 360
  361 VFLSIEYIRF QNLPPLGSAI ELQLRRFADD RDHSGPLIIS YLYLLFGIST PLLMNNSPMG 420
  421 LIGLGIGDSL ASIIGKRYGR IRWKGTQKTL EGTLAFIVTS FIVCLVLLRF DKAAIFNHLT 480
  481 TLQLLTLCTL SGVLEGNSVL NDNILIPAFM MICEKLITL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) SEC59 SRP102

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..59] ORFEUS 7.19 FAT domain of focal adhesion kinase
    2 View Details [60..66]
    [87..204]    		 ORFEUS 9.29 (+)-bornyl diphosphate synthase
    3 View Details [67..86]
    [205..383]    		 ORFEUS 9.29 (+)-bornyl diphosphate synthase
    4 View Details [384..519] Pfam 41.431798 No description for PF01879 was found. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle