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Protein Overview: SEC61

General Information:
Name(s) found: SEC61 / YLR378C [SGD]
Description(s) found:
Found 31 descriptions.
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  • Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 480 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum lumen [IDALink to PubMed article]
    integral to endoplasmic reticulum membrane [IDALink to PubMed article]
    Sec61 translocon complex [TASLink to PubMed article]
    Biological Process: SRP-dependent cotranslational protein targeting to membrane, translocation [TASLink to PubMed article]
    protein targeting to ER [IMPLink to PubMed article]
    posttranslational protein targeting to membrane, translocation [TASLink to PubMed article]
    Molecular Function: protein transporter activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSNRVLDLF KPFESFLPEV IAPERKVPYN QKLIWTGVSL LIFLILGQIP LYGIVSSETS  60
   61 DPLYWLRAML ASNRGTLLEL GVSPIITSSM IFQFLQGTQL LQIRPESKQD RELFQIAQKV 120
  121 CAIILILGQA LVVVMTGNYG APSDLGLPIC LLLIFQLMFA SLIVMLLDEL LSKGYGLGSG 180
  181 ISLFTATNIA EQIFWRAFAP TTVNSGRGKE FEGAVIAFFH LLAVRKDKKR ALVEAFYRTN 240
  241 LPNMFQVLMT VAIFLFVLYL QGFRYELPIR STKVRGQIGI YPIKLFYTSN TPIMLQSALT 300
  301 SNIFLISQIL FQKYPTNPLI RLIGVWGIRP GTQGPQMALS GLAYYIQPLM SLSEALLDPI 360
  361 KTIVYITFVL GSCAVFSKTW IEISGTSPRD IAKQFKDQGM VINGKRETSI YRELKKIIPT 420
  421 AAAFGGATIG ALSVGSDLLG TLGSGASILM ATTTIYGYYE AAAKEGGFTK NLVPGFSDLM 480
  481

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) SBH1 SEC61 SSS1
    View Details Qiu et al. (2008) SBH1 SEC61 SEC62 SEC63 SEC66 SEC72 SSH1 SSS1 STT3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen RAD6 SEC61 1 Unpublished Fields Lab Data
    View Screen VAM7 SEC61 1 Unpublished Fields Lab Data
    View Screen CDC16 SEC61 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data SEC61 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..72] MSA 1.110984 View MSA. No confident structure predictions are available.
    2 View Details [73..480] Pfam 12.017729 eubacterial secY protein No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ribonucleoprotein binding
    		•  5.96221631042313 bayes_pls_golite062009
  • protein transporter activity
    		•  5.55929343005534 bayes_pls_golite062009
  • transporter activity
    		•  3.32223562584466 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  3.22714325269757 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven protein transmembrane transporter activity
    		•  2.12732472524264 bayes_pls_golite062009
  • macromolecule transmembrane transporter activity
    		•  2.12732472524264 bayes_pls_golite062009
  • protein transmembrane transporter activity
    		•  1.76187269823414 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.67782980643723 bayes_pls_golite062009
  • binding
    		•  1.4562802789412 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.42890247609405 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  1.15847548838424 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  1.15316743403707 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  1.10003802565492 bayes_pls_golite062009
  • peptide transporter activity
    		•  1.01893828721893 bayes_pls_golite062009
  • protein binding
    		•  0.674651002700028 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle