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Protein Overview: SRGAP3

General Information:
Name(s) found: SRGAP3 [HGNC (HUGO)]
Description(s) found:
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  • gi|48429207|sp|O43295.3|SRGP2_HUMAN RecName: Full=SLIT-ROBO Rho GTPase-activating protein 3; Short=srGAP3; AltName: Full=srGAP2; AltName: Full=WAVE-associated Rac GTPase-activating protein; Short=WRP; AltName: Full=Mental disorder-associated GAP; AltName: [NCBI NR]
  • gi|24307967|ref|NP_055665.1| SLIT-ROBO Rho GTPase activating protein 3 isoform a [Homo sapiens] [NCBI NR]
  • gi|22773874|gb|AAN07095.1|AF427144_1 MEGAP transcript variant a [Homo sapiens] [NCBI NR]
  • SLIT-ROBO Rho GTPase activating protein 3 [HGNC (HUGO)]
  • SLIT-ROBO Rho GTPase-activating protein 3 OS=Homo sapiens GN=SRGAP3 PE=1 SV=3 [Swiss-Prot]
  • (O43295) SLIT-ROBO Rho GTPase activating protein 2 (srGAP2) (srGAP3) (WAVE-associated Rac GTPase activating protein) (WRP) (Mental disorder-associated GAP) (Rho-GTPase-activating protein 14) [Swiss-Prot]
  • MEGAP transcript variant a [hmr_yeast5_DM3-1_pombe.fasta]
  • SLIT-ROBO Rho GTPase-activating protein 2; SLIT-ROBO Rho GTPase-activating protein 3; WAVE-associated Rac GTPase activating protein [HMR_022704.fasta]
  • SLIT-ROBO Rho GTPase-activating protein 2 [Homo sapiens]gi|22773874|gb|AAN07095.1| MEGAP transcript variant a [Homo sapiens]gi|48429207|sp|O43295|SGA2_HUMAN SLIT-ROBO Rho GTPase activating protein 2 (srGAP2) (srGAP3) (WAVE-associated Rac GTPase activati [nrdb_11152004_Chlamydomonas]
  • SLIT-ROBO Rho GTPase activating protein 3 (srGAP3) (srGAP2) (WAVE-associated Rac GTPase activating protein) (WRP) (Mental disorder-associated GAP) (Rho-GTPase-activating protein 14) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 Splice Isoform 1 of SLIT-ROBO Rho GTPase-activating protein 3 [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • SLIT-ROBO Rho GTPase activating protein 3 isoform a [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • Tax_Id=9606 Splice Isoform 1 of SLIT-ROBO Rho GTPase activating protein 3 [EBI-IPI_human_3.04_03-07-2005_reverse.fasta]
  • SLIT-ROBO Rho GTPase-activating protein 2; SLIT-ROBO Rho GTPase-activating protein 3; WAVE-associated Rac GTPase activating protein [Homo sapiens] [HumanGallus06162005.fasta]
  • SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE-associated Rac GTPase-activating protein) (WRP) (Mental disorder-associated GAP) (Rho GTPase-activating protein 14) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • MEGAP transcript variant a [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 Isoform 1 of SLIT-ROBO Rho GTPase-activating protein 3 [EBI-IPI_human_3.23_11-02-2006_con_reversed.fasta]
  • Tax_Id=9606 SPLICE ISOFORM 1 OF SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN 2 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • RecName: Full=SLIT-ROBO Rho GTPase-activating protein 3; Short=srGAP3; AltName: Full=srGAP2; AltName: Full=WAVE-associated Rac GTPase-activating protein; Short=WRP; AltName: Full=Mental disorder-associated GAP; AltName: Full=Rho GTPase-activating protein [NCBI-RefSeq_human_na_10-15-2008_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=SRGAP3 Isoform 1 of SLIT-ROBO Rho GTPase-activating protein 3 [human-ipi-250309-contam.fasta]
  • SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE-associated Rac GTPase-activating protein) (WRP) (Mental disorder-associated GAP) (Rho-GTPase-activating protein 14) [nr-271106-contam.fasta]
  • IPI:IPI00218087.1|SWISS-PROT:O43295-1|ENSEMBL:ENSP00000373347|REFSEQ:NP_055665|VEGA:OTTHUMP00000115707;OTTHUMP00000170165 Tax_Id=9606 Gene_Symbol=SRGAP3 Isoform 1 of SLIT-ROBO Rho GTPase-activating protein 3 [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=SRGAP3 Isoform 1 of SLIT-ROBO Rho GTPase-activating protein 3 ENSG00000196220 IPI00218087 IPI00412209 IPI00847462 IPI00412210 IPI00843878 IPI00792604 IPI00795711 [drosphohumanreversed.fasta]
  • O43295;Q8IX13;Q8IZV8; RecName: Full=SLIT-ROBO Rho GTPase-activating protein 3; AltName: Full=srGAP2; AltName: Full=WAVE-associated Rac GTPase-activating protein; AltName: Full=Mental disorder-associated GAP; AltName: Full=Rho GTPase-activating protein 14; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Isoform 1 of SLIT-ROBO Rho GTPase-activating protein 3 OS=Homo sapiens GN=SRGAP3 [011711_HMR.fasta]
  • GeneSymbol=SRGAP3 Synonyms=ARHGAP14|KIAA0411|MEGAP|SRGAP2|WRP SLIT-ROBO Rho GTPase-activating protein 3 isoform a [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00218087.1|SWISS-PROT:O43295-1|ENSEMBL:ENSP00000373347|REFSEQ:NP_055665|VEGA:OTTHUMP00000115707 Tax_Id=9606 Gene_Symbol=SRGAP3 Isoform 1 of SLIT-ROBO Rho GTPase-activating protein 3 [ipi.HUMAN.20110912.fasta]
  • SLIT-ROBO Rho GTPase-activating protein 3 GN=SRGAP3 [Doctor+uniprot-HUMAN-120911.fasta]
    • Organism: Homo sapiens
    Length: 1099 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSQTKFKKD KEIIAEYEAQ IKEIRTQLVE QFKCLEQQSE SRLQLLQDLQ EFFRRKAEIE  60
   61 LEYSRSLEKL AERFSSKIRS SREHQFKKDQ YLLSPVNCWY LVLHQTRRES RDHATLNDIF 120
  121 MNNVIVRLSQ ISEDVIRLFK KSKEIGLQMH EELLKVTNEL YTVMKTYHMY HAESISAESK 180
  181 LKEAEKQEEK QFNKSGDLSM NLLRHEDRPQ RRSSVKKIEK MKEKRQAKYS ENKLKCTKAR 240
  241 NDYLLNLAAT NAAISKYYIH DVSDLIDCCD LGFHASLART FRTYLSAEYN LETSRHEGLD 300
  301 VIENAVDNLD SRSDKHTVMD MCNQVFCPPL KFEFQPHMGD EVCQVSAQQP VQTELLMRYH 360
  361 QLQSRLATLK IENEEVRKTL DATMQTLQDM LTVEDFDVSD AFQHSRSTES VKSAASETYM 420
  421 SKINIAKRRA NQQETEMFYF TKFKEYVNGS NLITKLQAKH DLLKQTLGEG ERAECGTTRP 480
  481 PCLPPKPQKM RRPRPLSVYS HKLFNGSMEA FIKDSGQAIP LVVESCIRYI NLYGLQQQGI 540
  541 FRVPGSQVEV NDIKNSFERG EDPLVDDQNE RDINSVAGVL KLYFRGLENP LFPKERFQDL 600
  601 ISTIKLENPA ERVHQIQQIL VTLPRVVIVV MRYLFAFLNH LSQYSDENMM DPYNLAICFG 660
  661 PTLMHIPDGQ DPVSCQAHIN EVIKTIIIHH EAIFPSPREL EGPVYEKCMA GGEEYCDSPH 720
  721 SEPGAIDEVD HDNGTEPHTS DEEVEQIEAI AKFDYMGRSP RELSFKKGAS LLLYHRASED 780
  781 WWEGRHNGVD GLIPHQYIVV QDMDDAFSDS LSQKADSEAS SGPLLDDKAS SKNDLQSPTE 840
  841 HISDYGFGGV MGRVRLRSDG AAIPRRRSGG DTHSPPRGLG PSIDTPPRAA ACPSSPHKIP 900
  901 LTRGRIESPE KRRMATFGSA GSINYPDKKA LSEGHSMRST CGSTRHSSLG DHKSLEAEAL 960
  961 AEDIEKTMST ALHELRELER QNTVKQAPDV VLDTLEPLKN PPGPVSSEPA SPLHTIVIRD1020
 1021 PDAAMRRSSS SSTEMMTTFK PALSARLAGA QLRPPPMRPV RPVVQHRSSS SSSSGVGSPA1080
 1081 VTPTEKMFPN SSADKSGTM

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..324] PSI-BLAST 23.0 Heavy meromyosin subfragment
    2 View Details [325..698] PSI-BLAST 47.0 Crystal Structure of the Human Beta2-Chimaerin
    3 View Details [699..876] PSI-BLAST 7.045757 No description for 2dl8A was found.
    4 View Details [877..928] deduced N/A No confident structure predictions are available.
    5 View Details [929..1099] MSA 7.206997 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • Rho GTPase activator activity
    		•  4.58620967349979 bayes_pls_golite062009
  • Rac GTPase activator activity
    		•  4.48279904625182 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  3.42802398019084 bayes_pls_golite062009
  • binding
    		•  2.79128751898373 bayes_pls_golite062009
  • GTPase regulator activity
    		•  2.70614727793157 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  2.68579854252375 bayes_pls_golite062009
  • actin binding
    		•  2.59114492135519 bayes_pls_golite062009
  • tubulin binding
    		•  2.31518443151057 bayes_pls_golite062009
  • guanyl-nucleotide exchange factor activity
    		•  2.06038764955701 bayes_pls_golite062009
  • enzyme regulator activity
    		•  1.9750017471254 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  1.95738547986197 bayes_pls_golite062009
  • motor activity
    		•  1.59872328451279 bayes_pls_golite062009
  • microtubule binding
    		•  1.39416664093439 bayes_pls_golite062009
  • Rho GTPase binding
    		•  1.34980300847466 bayes_pls_golite062009
  • protein binding
    		•  1.29100556128076 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.25507073225414 bayes_pls_golite062009
  • signal transducer activity
    		•  1.25507073225414 bayes_pls_golite062009
  • Ras GTPase activator activity
    		•  1.09070479183477 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.08577758274384 bayes_pls_golite062009
  • Rho guanyl-nucleotide exchange factor activity
    		•  0.967362611034944 bayes_pls_golite062009
  • Ras guanyl-nucleotide exchange factor activity
    		•  0.958295643211986 bayes_pls_golite062009
  • actin filament binding
    		•  0.937704425867942 bayes_pls_golite062009
  • GTPase activator activity
    		•  0.717730683557543 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.480348726111787 bayes_pls_golite062009
  • receptor activity
    		•  0.434186339265983 bayes_pls_golite062009
  • DNA binding
    		•  0.418154636457321 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.38335246506929 bayes_pls_golite062009
  • enzyme activator activity
    		•  0.298334474872045 bayes_pls_golite062009
  • microfilament motor activity
    		•  0.0746966011130201 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle