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Protein Overview: LGTN

General Information:
Name(s) found: LGTN [HGNC (HUGO)]
Description(s) found:
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  • gi|56699485|ref|NP_008824.2| ligatin [Homo sapiens] [NCBI NR]
  • gi|55961045|emb|CAI13534.1| ligatin [Homo sapiens] [NCBI NR]
  • gi|37589314|gb|AAH58905.1| Ligatin [Homo sapiens] [NCBI NR]
  • gi|37514865|gb|AAH39134.2| Ligatin [Homo sapiens] [NCBI NR]
  • gi|16306782|gb|AAH01585.1| Ligatin [Homo sapiens] [NCBI NR]
  • gi|158957575|sp|P41214.3|LIGA_HUMAN RecName: Full=Ligatin; AltName: Full=Hepatocellular carcinoma-associated antigen 56 [NCBI NR]
  • gi|156630893|sp|P41214|LIGA_HUMAN Ligatin (Hepatocellular carcinoma-associated antigen 56) [NCBI NR]
  • gi|119613942|gb|EAW93536.1| ligatin, isoform CRA_a [Homo sapiens] [NCBI NR]
  • ligatin [HGNC (HUGO)]
  • Ligatin OS=Homo sapiens GN=LGTN PE=1 SV=3 [Swiss-Prot]
  • Eukaryotic translation initiation factor 2D OS=Homo sapiens GN=EIF2D PE=1 SV=3 [Swiss-Prot]
  • Ligatin [hmr_yeast5_DM3-1_pombe.fasta]
  • Ligatin [Homo sapiens]gi|16306782|gb|AAH01585.1| Ligatin [Homo sapiens]gi|37514865|gb|AAH39134.2| Ligatin [Homo sapiens] [nrdb_11152004_Chlamydomonas]
  • Tax_Id=9606 ligatin [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • ligatin [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • Ligatin (Hepatocellular carcinoma-associated antigen 56) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • ligatin, isoform CRA_a [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Ligatin [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 LIGATIN [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=LGTN Isoform 1 of Ligatin [human-ipi-250309-contam.fasta]
  • IPI:IPI00013160.2|SWISS-PROT:P41214-1|ENSEMBL:ENSP00000271764|REFSEQ:NP_008824|H-INV:HIT000030499|VEGA:OTTHUMP00000034537 Tax_Id=9606 Gene_Symbol=LGTN Isoform 1 of Ligatin [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=LGTN Isoform 1 of Ligatin ENSG00000143486 IPI00013160 IPI00514767 IPI00183443 [drosphohumanreversed.fasta]
  • Tax_Id=9606 Gene_Symbol=LGTN ligatin [EBI-IPI_human_3.30_06-28-2007_con_reversed.fasta]
  • P41214;Q5SY40;Q8IXV3;Q96DG3;Q96TG7;Q9NR27;Q9NSN0;Q9NV18;Q9NZ21; RecName: Full=Ligatin; AltName: Full=Hepatocellular carcinoma-associated antigen 56; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Isoform 1 of Ligatin OS=Homo sapiens GN=LGTN [011711_HMR.fasta]
  • GeneSymbol=EIF2D Synonyms=HCA56|LGTN ligatin [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • Isoform 1 of Eukaryotic translation initiation factor 2D OS=Homo sapiens GN=EIF2D [122011_hum.fasta]
  • IPI:IPI00013160.2|SWISS-PROT:P41214-1|ENSEMBL:ENSP00000271764|REFSEQ:NP_008824|H-INV:HIT000030499|VEGA:OTTHUMP00000034537 Tax_Id=9606 Gene_Symbol=EIF2D;LGTN Isoform 1 of Eukaryotic translation initiation factor 2D [ipi.HUMAN.20110912.fasta]
  • Eukaryotic translation initiation factor 2D GN=EIF2D [Doctor+uniprot-HUMAN-120911.fasta]
  • Tax_Id=9606 Gene_Symbol=EIF2D Isoform 1 of Eukaryotic translation initiation factor 2D [human-ipi-270911-contam-BSA.fasta]
  • IPI:IPI00013160.2|SWISS-PROT:P41214-1|ENSEMBL:ENSP00000271764|REFSEQ:NP_008824|H-INV:HIT000030499|VEGA:OTTHUMP00000034537 Tax_Id=9606 Gene_Symbol=EIF2D Isoform 1 of Eukaryotic translation initiation factor 2D [ipi.HUMAN.fasta.20110927]
    • Organism: Homo sapiens
    Length: 584 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFAKAFRVKS NTAIKGSDRR KLRADVTTAF PTLGTDQVSE LVPGKEELNI VKLYAHKGDA  60
   61 VTVYVSGGNP ILFELEKNLY PTVYTLWSYP DLLPTFTTWP LVLEKLVGGA DLMLPGLVMP 120
  121 PAGLPQVQKG DLCAISLVGN RAPVAIGVAA MSTAEMLTSG LKGRGFSVLH TYQDHLWRSG 180
  181 NKSSPPSIAP LALDSADLSE EKGSVQMDST LQGDMRHMTL EGEEENGEVH QAREDKSLSE 240
  241 APEDTSTRGL NQDSTDSKTL QEQMDELLQQ CFLHALKCRV KKADLPLLTS TFLGSHMFSC 300
  301 CPEGRQLDIK KSSYKKLSKF LQQMQQEQII QVKELSKGVE SIVAVDWKHP RITSFVIPEP 360
  361 SPTSQTIQEG SREQPYHPPD IKPLYCVPAS MTLLFQESGH KKGSFLEGSE VRTIVINYAK 420
  421 KNDLVDADNK NLVRLDPILC DCILEKNEQH TVMKLPWDSL LTRCLEKLQP AYQVTLPGQE 480
  481 PIVKKGRICP IDITLAQRAS NKKVTVVRNL EAYGLDPYSV AAILQQRCQA STTVNPAPGA 540
  541 KDSLQVQIQG NQVHHLGWLL LEEYQLPRKH IQGLEKALKP GKKK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..180] PSI-BLAST 40.39794 No description for 2ausC was found.
    2 View Details [181..248] MSA 1.119986 View MSA. No confident structure predictions are available.
    3 View Details [249..358] deduced N/A No confident structure predictions are available.
    4 View Details [359..468] FFAS03 1.32 Solution structure of the SWIB/MDM2 domain of the hypothetical protein At5g08430 from Arabidopsis thaliana
    5 View Details [469..584] PSI-BLAST 30.39794 HUMAN TRANSLATION INITIATION FACTOR EIF1, NMR, 29 STRUCTURES

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • structural molecule activity
    		•  4.72233209840291 bayes_pls_golite062009
  • protein binding
    		•  2.52181725362933 bayes_pls_golite062009
  • binding
    		•  2.18328191469694 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.77240364924631 bayes_pls_golite062009
  • transcription activator activity
    		•  0.995535823852062 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.464336112087611 bayes_pls_golite062009
  • basal transcription repressor activity
    		•  0.307849920263354 bayes_pls_golite062009
  • transcription factor binding
    		•  0.203735997461782 bayes_pls_golite062009
  • catalytic activity
    		•  0.151165614150825 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.125030292437611 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.012901717642134 bayes_pls_golite062009
    5
    Term Confidence Notes
  • translation initiation factor activity
    		•  6.56930940751046 bayes_pls_golite062009
  • translation regulator activity
    		•  2.27579767245564 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  2.25914933413253 bayes_pls_golite062009
  • binding
    		•  1.99916637558859 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.69119554284364 bayes_pls_golite062009
  • protein binding
    		•  1.47118967208188 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle