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Protein Overview: MCPH1-PA

General Information:
Name(s) found: MCPH1-PA / FBpp0290643 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • The gene Microcephalin is referred to in FlyBase by the symbol Dmel\MCPH1 (CG42572, FBgn0260959). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:7783499..7791429. It has the cytological map location 48C5. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process</span>: mushroom body development. 11 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 779 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA]
    Biological Process: embryonic development [IMP]
    mushroom body development [IMP]
    pole cell formation [IMP]
    mitosis [IMP]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTNEPSITN KLRSLLLDDQ AARDRLMLKP ALAVSKAISQ HRSEFHQDEN EAGAEGSAAK  60
   61 PDPPIGAATP TRQEGHWARL QQDLNSPNAA LRLRAIRALK SPTKSAYNTF DVPLAEQSII 120
  121 TMEERNPQEP PSLPELLKDI VVYVEVRTGN DNRSEGVKSI IAKMGAQVKD RLTRTTTHVV 180
  181 FKDGLLSTYK KATEWNIPVV SILWIEACKV QLKICDPKQF PISNIRMYEY PELFGKMPRV 240
  241 KFMQPDSELN QRPRKRQGTP TSSKDNEPGS TNKRAQTGTP TTTTPKNDIS RFFRAINHNK 300
  301 PSDDEAIESP ATKLLNRISS GCYTPLPAGG TPQLMGTNGS GDAVAQKVQA QKSLQFGEQT 360
  361 DSNTPQAKPS STSRPRRSTV DPPPVMTPPV RTTRRRSCVA EISSPAATDT RMTRRRSSLL 420
  421 TSTVIHEADP TQTAVAEPRM TRRRSSLLGI AKQAEETAQR QTIQPITEEL APVEENRNSI 480
  481 IMAETNIINN TNCLEQSIEI TAVEAEASFK ADRRGTLYAS ELMDISSPRR RSVAKSSLEL 540
  541 RQENLAPRAR QSLSNVTTQT SFLDVEQQVT PLFSSTRLPT GQTTGNRRRT IFNMDMDVIN 600
  601 ESIERMNQSH RMSLALANKA ELGESCQVHE QEPPQAEPVP SQEPKRRRLF NPNDEVVISP 660
  661 AMSNRKSRLS ITGSGSSSSV QKRRRSLATP AKSSSSELCA TTPLSKAVTN KEAEKSKSNT 720
  721 EISEASLDAV PEVKKSTSNA GEENEKPKGK SRTRIRTLVH TNMHQEQINV IRKVGNTTE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..86] deduced N/A No confident structure predictions are available.
    2 View Details [87..259] FFAS03 4.46 No description for 2d8mA was found.
    3 View Details [260..511] deduced N/A No confident structure predictions are available.
    4 View Details [512..628] MSA 3.202988 View MSA. No confident structure predictions are available.
    5 View Details [629..779] deduced N/A No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
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