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Protein Overview: Klp54D-PA

General Information:
Name(s) found: Klp54D-PA / FBpp0086005 [FlyBase]
Description(s) found:
Found 13 descriptions.
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  • The gene Kinesin-like protein at 54D is referred to in FlyBase by the symbol Dmel\Klp54D (CG15844, FBgn0004377). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:13444412..13451490. It has the cytological map location 54C5-54C8. Based on sequence similarity, it is predicted to have molecular function</span>: microtubule motor activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: microtubule-based movement. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 844 amino acids

    Gene Ontology:
    Cellular Component: heterotrimeric G-protein complex [IEA]
    kinesin complex [ISS]
    Biological Process: G-protein coupled receptor protein signaling pathway [IEA]
    microtubule-based movement [ISS]
    Molecular Function: ATP binding [IEA]
    microtubule motor activity [ISS]
    signal transducer activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGIWLVPCPR DILVLSKQST PYPAFAHSVA STQVTMVRRA SSVPHLNSSG GSSADSAGTS  60
   61 GSRRGRAPVA GSRGRKTPST TSTGQSQRQS SGSSSSMPRS RSLTNGMRRL SPQKGTGSSG 120
  121 GTGGGGGSSR NTPYFLRSRE NEIGSADTLE IVASKSTGSE ECSTPEDNIN VVVRVRPLND 180
  181 KEKRDRHGST LQFPGNGQVI LEGNDVGQKR SHNRDSVRVF TYNVVFEPGA TQEDILDYSG 240
  241 IKRIIEMGIE GFSCTAFCYG QTGSGKTHTL TGPPDLFVGK PNPKDPRHGL IFRSFLYLFQ 300
  301 LIKNRKDVNY VLKASFMEIY NERVIDLLNP GSARKPLAVR WSKKSGGFFV ENLFTVDCEE 360
  361 LDDLLAVLEE GMRNRAVGSH AMNDHSSRSH TILTVHILSD QQTDGGVFLS KHGKINFVDL 420
  421 AGSELTKKTM SEGKTLEEAN NINKSLMVLG YCISSLSDSK KRTGHIPYRD SQLTKLLADS 480
  481 LAGNGVTLMI ACVSPAHYNH AETLNTLRYA SRAKRIRTKP VIKMDPREAL ILSLKRDIHA 540
  541 LQMENDHLKA ALNLHHQAAP NGGPVENLLE LQLDRVSSGG GVPVPKVDLQ RLPELDGSEL 600
  601 AELVKLYMVE NESLRQENNH LFTVRETILR DQEIVCRENE RLLKKLEDVN KVCVRSPLIP 660
  661 ARPAISPTTG KETPGTEIWT NPEPLQSPPG PDLPIEQRMS ENANRRTDTA QKRIDQKRIA 720
  721 KNILIMANAF RKPDSDITKE LNLNPEEAHA KQSTEFMPDS ISIPATTIGL AETAVLDIMA 780
  781 ANLQQQRSIN LQLRREVEME RMPVSVACSL MMKYMLEHEE EDCLLSGFTQ KVNPFREKSS 840
  841 CSIL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..148] MSA 12.266997 View MSA. No confident structure predictions are available.
    2 View Details [149..421] PSI-BLAST 80.522879 Human Eg5 motor domain bound to Mg-ADP and monastrol
    3 View Details [422..618] PSI-BLAST 7.0 KINESIN (DIMERIC) FROM RATTUS NORVEGICUS
    4 View Details [619..676] deduced N/A No confident structure predictions are available.
    5 View Details [677..844] PSI-BLAST 4.221849 No description for 2iw5A was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • microtubule motor activity
    		•  7.68336791348661 bayes_pls_golite062009
  • plus-end-directed microtubule motor activity
    		•  4.97507344344589 bayes_pls_golite062009
  • GTPase activity
    		•  4.92902654551215 bayes_pls_golite062009
  • microfilament motor activity
    		•  4.176620576177 bayes_pls_golite062009
  • motor activity
    		•  4.04927796049806 bayes_pls_golite062009
  • transporter activity
    		•  3.10463051760206 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.95886887664984 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  2.95079405147356 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.87427509025394 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  2.85499564954033 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  2.85178667290149 bayes_pls_golite062009
  • actin-dependent ATPase activity
    		•  2.77140616759165 bayes_pls_golite062009
  • microtubule plus-end binding
    		•  2.71138928021716 bayes_pls_golite062009
  • tubulin binding
    		•  2.67743463093593 bayes_pls_golite062009
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  2.61775212528604 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  2.61467977505707 bayes_pls_golite062009
  • microtubule binding
    		•  2.59155206524122 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  2.57552435627908 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  2.57107347424517 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  2.57054427875021 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  2.50494515048649 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  2.43862163407966 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.4101693596493 bayes_pls_golite062009
  • ATPase activity
    		•  2.39535714892224 bayes_pls_golite062009
  • actin binding
    		•  2.2973522188675 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  2.07967285635739 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.91091452720653 bayes_pls_golite062009
  • G-protein coupled receptor activity
    		•  1.63949223587737 bayes_pls_golite062009
  • hydrolase activity
    		•  1.57549510726226 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.56325751172863 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.40384549325664 bayes_pls_golite062009
  • helicase activity
    		•  1.33212695797068 bayes_pls_golite062009
  • actin filament binding
    		•  1.28204719195916 bayes_pls_golite062009
  • protein binding
    		•  1.22129154759482 bayes_pls_golite062009
  • G-protein-coupled receptor binding
    		•  1.07726090199322 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  1.07479235523606 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.977237423302079 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.929901285538132 bayes_pls_golite062009
  • nucleotide binding
    		•  0.922442819194247 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.920987930180051 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.920926158369519 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.777787753097919 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.683309012097319 bayes_pls_golite062009
  • signal transducer activity
    		•  0.683309012097319 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.661834961742057 bayes_pls_golite062009
  • receptor activity
    		•  0.633514002718998 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.557919489256916 bayes_pls_golite062009
  • kinetochore binding
    		•  0.505370954958131 bayes_pls_golite062009
  • DNA binding
    		•  0.479412476059825 bayes_pls_golite062009
  • ATP binding
    		•  0.41092997612902 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.385813421701492 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.377870145186619 bayes_pls_golite062009
  • RNA helicase activity
    		•  0.34746349346164 bayes_pls_golite062009
  • lysine N-acetyltransferase activity
    		•  0.328186246219424 bayes_pls_golite062009
  • histone acetyltransferase activity
    		•  0.328186246219424 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.312171320541728 bayes_pls_golite062009
  • ATP-dependent RNA helicase activity
    		•  0.30832907234141 bayes_pls_golite062009
  • RNA-dependent ATPase activity
    		•  0.29532978396745 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  0.25143870859482 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  0.25143870859482 bayes_pls_golite062009
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
    		•  0.213018989352421 bayes_pls_golite062009
  • protein transporter activity
    		•  0.178442534411253 bayes_pls_golite062009
  • metabotropic serotonin receptor binding
    		•  0.178039386254807 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.17029946873911 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  0.123304946374679 bayes_pls_golite062009
  • mu-type opioid receptor binding
    		•  0.105073376987609 bayes_pls_golite062009
  • opioid receptor binding
    		•  0.105073376987609 bayes_pls_golite062009
  • minus-end-directed microtubule motor activity
    		•  0.068779631341469 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.0111338193708552 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • transcription regulator activity
    		•  3.3573497204506 bayes_pls_golite062009
  • binding
    		•  3.02779747447702 bayes_pls_golite062009
  • DNA binding
    		•  3.0205295442286 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.77547609431902 bayes_pls_golite062009
  • transcription factor activity
    		•  2.57014522504183 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.38135384233451 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.1457670954804 bayes_pls_golite062009
  • actin binding
    		•  2.03209305727522 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.94512319394414 bayes_pls_golite062009
  • protein binding
    		•  1.88087411289001 bayes_pls_golite062009
  • transcription activator activity
    		•  1.7593420956408 bayes_pls_golite062009
  • chromatin binding
    		•  1.68308196781423 bayes_pls_golite062009
  • G-protein coupled receptor activity
    		•  1.66519556937355 bayes_pls_golite062009
  • receptor activity
    		•  1.16684800542624 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.10327547436113 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.06075239560835 bayes_pls_golite062009
  • signal transducer activity
    		•  0.912169249499274 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.912169249499274 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.86319868225781 bayes_pls_golite062009
  • actin filament binding
    		•  0.81690252782831 bayes_pls_golite062009
  • lysine N-acetyltransferase activity
    		•  0.6697807021052 bayes_pls_golite062009
  • histone acetyltransferase activity
    		•  0.6697807021052 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.57338514991304 bayes_pls_golite062009
  • protein deacetylase activity
    		•  0.47177024356295 bayes_pls_golite062009
  • transcription factor binding
    		•  0.45727836611098 bayes_pls_golite062009
  • histone deacetylase activity
    		•  0.426080122313218 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.0818464406491994 bayes_pls_golite062009
  • histone binding
    		•  0.0391625783266718 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle