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Protein Overview: Cyp313a3-PA

General Information:
Name(s) found: Cyp313a3-PA / FBpp0082086 [FlyBase]
Description(s) found:
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  • gi|24646221|ref|NP_650170.2| Cyp313a3 [Drosophila melanogaster] [NCBI NR]
  • gi|23171090|gb|AAF54770.3| Cyp313a3 [Drosophila melanogaster] [NCBI NR]
  • gi|11386659|sp|Q9VGB3.2|CP133_DROME RecName: Full=Probable cytochrome P450 313a3; AltName: Full=CYPCCCXIIIA3 [NCBI NR]
  • Probable cytochrome P450 313a3 OS=Drosophila melanogaster GN=Cyp313a3 PE=3 SV=2 [Swiss-Prot]
  • (Q9VGB3) Probable cytochrome P450 313a3 (EC 1.14.-.-) (CYPCCCXIIIA3) [Swiss-Prot]
  • The gene Cyp313a3 is referred to in FlyBase by the symbol Dmel\Cyp313a3 (CG10093, FBgn0038007). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:8063001..8064831. It has the cytological map location 87B3. Based on sequence similarity, it is predicted to have molecular function</span>: electron carrier activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: oxidation reduction. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • >CG10093-PA translation from_gene[CG10093 Cyp313a3 FBgn0038007] seq_release:3 mol_weight=56196 cds_boundaries:(3R:8,063,023..8,064,850[-]) aa_length:492 transcript_info:[CG10093-RA seq_release:3] gene_info:[gene symbol:Cyp313a3 FBgn0038007 gene_boundar [hmr_yeast5_DM3-1_pombe.fasta]
  • CG10093-PA [Drosophila melanogaster]gi|24646221|ref|NP_650170.2| CG10093-PA [Drosophila melanogaster]gi|11386659|sp|Q9VGB3|C133_DROME Probable cytochrome P450 313a3 (CYPCCCXIIIA3) [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=3R:complement(8063001..8063161,8063215..8063788,8063843..8063969,8064031..8064103,8064169..8064354,8064410..8064610,8064675..8064831); ID=FBpp0082086; name=Cyp313a3-PA; parent=FBgn0038007,FBtr0082617; dbxref=FlyBase:FBpp0082086,FlyBase_A [fly-100309-contam.fasta]
  • CG10093-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Probable cytochrome P450 313a3 (CYPCCCXIIIA3) [nr-271106-contam.fasta]
  • Cyp313a3 CG10093-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=3R:complement(8063001..8063161,8063215..8063788,8063843..8063969,8064031..8064103,8064169..8064354,8064410..8064610,8064675..8064831); ID=FBpp0082086; name=Cyp313a3-PA; parent=FBgn0038007,FBtr0082617; dbxref=FlyBase:FBpp0082086,FlyBase_Annotation_IDs:CG10093-PA,GB_protein:AAF54770.3,REFSEQ:NP_650170,GB_protein:AAF54770; MD5=3ea0e6d7d06bb6166a15701816331a67; length=492; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3R:complement(8063001..8063161,8063215..8063788,8063843..8063969,8064031..8064103,8064169..8064354,8064410..8064610,8064675..8064831); ID=FBpp0082086; name=Cyp313a3-PA; parent=FBgn0038007,FBtr0082617; dbxref=FlyBase:FBpp0082086,FlyBase_Annotation_IDs:CG10093-PA,GB_protein:AAF54770.3,REFSEQ:NP_650170,GB_protein:AAF54770; MD5=3ea0e6d7d06bb6166a15701816331a67; length=492; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • RT06949p OS=Drosophila melanogaster GN=Cyp313a3-RA PE=2 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=3R:complement(8063001..8063161,8063215..8063788,8063843..8063969,8064031..8064103,8064169..8064354,8064410..8064610,8064675..8064831); ID=FBpp0082086; name=Cyp313a3-PA; parent=FBgn0038007,FBtr0082617; dbxref=FlyBase:FBpp0082086,FlyBase_Annotation_IDs:CG10093-PA,GB_protein:AAF54770.3,REFSEQ:NP_650170,GB_protein:AAF54770,FlyMine:FBpp0082086,modMine:FBpp0082086; MD5=3ea0e6d7d06bb6166a15701816331a67; length=492; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=3R:complement(join(12238953..12239109,12238688..12238888,12238447..12238632,12238309..12238381,12238121..12238247,12237493..12238066,12237279..12237439)); ID=FBpp0082086; name=Cyp313a3-PA; parent=FBgn0038007,FBtr0082617; dbxref=FlyBase:FBpp0082086,FlyBase_Annotation_IDs:CG10093-PA,GB_protein:AAF54770.3,REFSEQ:NP_650170,GB_protein:AAF54770,FlyMine:FBpp0082086,modMine:FBpp0082086; MD5=3ea0e6d7d06bb6166a15701816331a67; length=492; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=3R:complement(join(12238953..12239109,12238688..12238888,12238447..12238632,12238309..12238381,12238121..12238247,12237493..12238066,12237279..12237439)); ID=FBpp0082086; name=Cyp313a3-PA; parent=FBgn0038007,FBtr0082617; dbxref=FlyBase:FBpp0082086,FlyBase_Annotation_IDs:CG10093-PA,GB_protein:AAF54770.3,REFSEQ:NP_650170,GB_protein:AAF54770,FlyMine:FBpp0082086,modMine:FBpp0082086; MD5=3ea0e6d7d06bb6166a15701816331a67; length=492; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • FBpp0082086 type=protein; loc=3R:complement(join(12238953..12239109,12238688..12238888,12238447..12238632,12238309..12238381,12238121..12238247,12237493..12238066,12237279..12237439)); ID=FBpp0082086; name=Cyp313a3-PA; parent=FBgn0038007,FBtr0082617; dbxref=FlyBase:FBpp0082086,FlyBase_Annotation_IDs:CG10093-PA,GB_protein:AAF54770.3,REFSEQ:NP_650170,GB_protein:AAF54770,FlyMine:FBpp0082086,modMine:FBpp0082086; MD5=3ea0e6d7d06bb6166a15701816331a67; length=492; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=3R:complement(join(12238953..12239109,12238688..12238888,12238447..12238632,12238309..12238381,12238121..12238247,12237493..12238066,12237279..12237439)); ID=FBpp0082086; name=Cyp313a3-PA; parent=FBgn0038007,FBtr0082617; dbxref=FlyBase:FBpp0082086,FlyBase_Annotation_IDs:CG10093-PA,GB_protein:AAF54770.3,REFSEQ:NP_650170,GB_protein:AAF54770,UniProt/Swiss-Prot:Q9VGB3,FlyMine:FBpp0082086,modMine:FBpp0082086; MD5=3ea0e6d7d06bb6166a15701816331a67; length=492; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 492 amino acids

    Gene Ontology:
    Cellular Component: membrane [NAS]
    microsome [NAS]
    Biological Process: oxidation reduction [IEA]
    Molecular Function: electron carrier activity [IEA][ISS][NAS]
    monooxygenase activity [IEA]
    heme binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDTFQLLLAV GVCFWIYFLW SRRRLYMMHF KIPGPMGLPI LGIAFEYLIT YKRKMSIRTK  60
   61 YMDIYGSTCL VWVGPTPFVI TRDPKIAEEI FLSPECLNRS SIFSKPVNSC TGDGLLSLEA 120
  121 SKWVDRRKNL NPAFKQNVLL SFLPIFNSEA KTLVAFLDSL VGQGEKKVRD DIVRWSFRIA 180
  181 TQTTVGTDVK KDASFKNDSV LKSYETFMKI IVMNVLLPFT HNKIFSTLGG FETQKALAKS 240
  241 NVNKMIGTIV DKKLMTKPES GSQPEITSVI NKAIELHRNG EMSREEVQSE CCSFVVAAFE 300
  301 TTGDTVYHAL ILLAMFPEHQ DTVYQELKEL FPVAGDFEVT YDDLQRMVFL ERVVNETLRL 360
  361 IPSVPFTPRE TIRDFRLSSG VVIPKGVGIG IDIFATHRNR DHWGTDPSSF NPDHFLPDNV 420
  421 RDRHPYAYIP FSKGRRNCIG WKYGLMSSKL ALSKILRNCK VSTSFRYEDL EFVDNIGMEL 480
  481 AQSPGLEFHR RT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..492] PSI-BLAST 92.522879 Crystal Structure of Human Microsomal P450 3A4

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • arachidonic acid monooxygenase activity
    		•  6.76823710927794 bayes_pls_golite062009
  • monooxygenase activity
    		•  5.57229509004705 bayes_pls_golite062009
  • steroid hydroxylase activity
    		•  5.04794778387361 bayes_pls_golite062009
  • arachidonic acid epoxygenase activity
    		•  4.80764258881036 bayes_pls_golite062009
  • retinoic acid 4-hydroxylase activity
    		•  3.76307535769621 bayes_pls_golite062009
  • oxygen binding
    		•  3.7203678182299 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
    		•  3.68151610133025 bayes_pls_golite062009
  • fluorene oxygenase activity
    		•  3.16634614522939 bayes_pls_golite062009
  • retinoic acid binding
    		•  3.04897926497756 bayes_pls_golite062009
  • retinoid binding
    		•  2.60220937953757 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
    		•  2.56821164444595 bayes_pls_golite062009
  • isoprenoid binding
    		•  2.47826119804163 bayes_pls_golite062009
  • oxidoreductase activity
    		•  2.35847923992364 bayes_pls_golite062009
  • 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity
    		•  2.30416050662077 bayes_pls_golite062009
  • demethylase activity
    		•  2.17116413461366 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen
    		•  2.15105968497418 bayes_pls_golite062009
  • vitamin D 24-hydroxylase activity
    		•  1.81919676974797 bayes_pls_golite062009
  • oxysterol 7-alpha-hydroxylase activity
    		•  1.71732865382274 bayes_pls_golite062009
  • sterol 14-demethylase activity
    		•  1.68985995159863 bayes_pls_golite062009
  • vitamin D3 25-hydroxylase activity
    		•  1.65825585934141 bayes_pls_golite062009
  • vitamin D 25-hydroxylase activity
    		•  1.65825585934141 bayes_pls_golite062009
  • fatty acid (omega-1)-hydroxylase activity
    		•  1.65569090470706 bayes_pls_golite062009
  • electron carrier activity
    		•  1.48516712188486 bayes_pls_golite062009
  • testosterone 6-beta-hydroxylase activity
    		•  1.4661447981611 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
    		•  1.46109575978397 bayes_pls_golite062009
  • binding
    		•  1.2866152532988 bayes_pls_golite062009
  • 25-hydroxycholecalciferol-24-hydroxylase activity
    		•  1.06487564122685 bayes_pls_golite062009
  • steroid 17-alpha-monooxygenase activity
    		•  0.918503562996019 bayes_pls_golite062009
  • flavonoid 3'-monooxygenase activity
    		•  0.89030345144459 bayes_pls_golite062009
  • ecdysteroid 25-hydroxylase activity
    		•  0.89030345144459 bayes_pls_golite062009
  • catalytic activity
    		•  0.608111453189583 bayes_pls_golite062009
  • cholesterol monooxygenase (side-chain-cleaving) activity
    		•  0.276594551871869 bayes_pls_golite062009
  • arachidonic acid 11,12-epoxygenase activity
    		•  0.0888154993183798 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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