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Protein Overview: ash2-PC

General Information:
Name(s) found: ash2-PC / FBpp0084040 [FlyBase]
Description(s) found:
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  • gi|28571870|ref|NP_788735.1| absent, small, or homeotic discs 2, isoform C [Drosophila melanogaster] [NCBI NR]
  • gi|28381454|gb|AAO41602.1| absent, small, or homeotic discs 2, isoform C [Drosophila melanogaster] [NCBI NR]
  • gi|24797078|gb|AAC47328.2| trithorax protein ASH2 [Drosophila melanogaster] [NCBI NR]
  • gi|15291917|gb|AAK93227.1| LD31680p [Drosophila melanogaster] [NCBI NR]
  • Set1/Ash2 histone methyltransferase complex subunit ASH2 OS=Drosophila melanogaster GN=ash2 PE=1 SV=2 [Swiss-Prot]
  • The gene absent, small, or homeotic discs 2 is referred to in FlyBase by the symbol Dmel\ash2 (CG6677, FBgn0000139). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:20475769..20479099. It has the cytological map location 96A13. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: zinc ion binding; protein binding. There is experimental evidence that it is involved in the biological process</span>: imaginal disc-derived wing vein specification; chromatin-mediated maintenance of transcription; imaginal disc-derived wing morphogenesis. 28 alleles are reported. The phenotypes of these alleles are annotated with 17 unique terms, many of which group under: adult segment; organ system; thoracic segment; adult mesothoracic segment; appendage segment; adult metathoracic segment; imaginal precursor; adult; dorsal thoracic disc; multi-cell-component structure; antennal segment; mouthpart. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
  • >CG6677-PC translation from_gene[CG6677 ash2 FBgn0000139] seq_release:3 mol_weight=63230 cds_boundaries:(3R:20,466,608..20,469,578[+]) aa_length:556 transcript_info:[CG6677-RC seq_release:3] gene_info:[gene symbol:ash2 FBgn0000139 gene_boundaries:(3R:2 [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q94545) Trithorax protein ASH2 (LD31680p) (CG6677-PC) [DrosMelano7227.FASTAC.txt]
  • CG6677-PC, isoform C [Drosophila melanogaster]gi|28571870|ref|NP_788735.1| CG6677-PC [Drosophila melanogaster]gi|15291917|gb|AAK93227.1| LD31680p [Drosophila melanogaster]gi|24797078|gb|AAC47328.2| trithorax protein ASH2 [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=3R:join(20475951..20476066,20476127..20476311,20476372..20476716,20477583..20477963,20478032..20478312,20478504..20478761,20478820..20478924); ID=FBpp0084040; name=ash2-PC; parent=FBgn0000139,FBtr0084660; dbxref=FlyBase:FBpp0084040,FlyBa [fly-100309-contam.fasta]
  • CG6677-PC, isoform C [Drosophila melanogaster] [nr-271106-contam.fasta]
  • absent, small, or homeotic discs 2 CG6677-PC, isoform C [Drosophila melanogaster] [nr-271106-contam.fasta]
  • trithorax protein ASH2 [Drosophila melanogaster] [nr-271106-contam.fasta]
  • LD31680p [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=3R:join(20475951..20476066,20476127..20476311,20476372..20476716,20477583..20477963,20478032..20478312,20478504..20478761,20478820..20478924); ID=FBpp0084040; name=ash2-PC; parent=FBgn0000139,FBtr0084660; dbxref=FlyBase:FBpp0084040,FlyBase_Annotation_IDs:CG6677-PC,GB_protein:AAO41602.1,REFSEQ:NP_788735,GB_protein:AAO41602; MD5=9a2a20a4332f4e530cc6d84f7e016cd9; length=556; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3R:join(20475951..20476066,20476127..20476311,20476372..20476716,20477583..20477963,20478032..20478312,20478504..20478761,20478820..20478924); ID=FBpp0084040; name=ash2-PC; parent=FBgn0000139,FBtr0084660; dbxref=FlyBase:FBpp0084040,FlyBase_Annotation_IDs:CG6677-PC,GB_protein:AAO41602.1,REFSEQ:NP_788735,GB_protein:AAO41602; MD5=9a2a20a4332f4e530cc6d84f7e016cd9; length=556; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Absent, small, or homeotic discs 2, isoform C OS=Drosophila melanogaster GN=ash2 PE=2 SV=2 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=3R:join(20475951..20476066,20476127..20476311,20476372..20476716,20477583..20477963,20478032..20478312,20478504..20478761,20478820..20478924); ID=FBpp0084040; name=ash2-PC; parent=FBgn0000139,FBtr0084660; dbxref=FlyBase:FBpp0084040,FlyBase_Annotation_IDs:CG6677-PC,GB_protein:AAO41602.1,REFSEQ:NP_788735,GB_protein:AAO41602,FlyMine:FBpp0084040,modMine:FBpp0084040; MD5=9a2a20a4332f4e530cc6d84f7e016cd9; length=556; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=3R:join(24650229..24650344,24650405..24650589,24650650..24650994,24651861..24652241,24652310..24652590,24652782..24653039,24653098..24653202); ID=FBpp0084040; name=ash2-PC; parent=FBgn0000139,FBtr0084660; dbxref=FlyBase:FBpp0084040,FlyBase_Annotation_IDs:CG6677-PC,GB_protein:AAO41602.1,REFSEQ:NP_788735,GB_protein:AAO41602,FlyMine:FBpp0084040,modMine:FBpp0084040; MD5=9a2a20a4332f4e530cc6d84f7e016cd9; length=556; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=3R:join(24650229..24650344,24650405..24650589,24650650..24650994,24651861..24652241,24652310..24652590,24652782..24653039,24653098..24653202); ID=FBpp0084040; name=ash2-PC; parent=FBgn0000139,FBtr0084660; dbxref=FlyBase:FBpp0084040,FlyBase_Annotation_IDs:CG6677-PC,GB_protein:AAO41602.1,REFSEQ:NP_788735,GB_protein:AAO41602,FlyMine:FBpp0084040,modMine:FBpp0084040; MD5=9a2a20a4332f4e530cc6d84f7e016cd9; length=556; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • FBpp0084040 type=protein; loc=3R:join(24650229..24650344,24650405..24650589,24650650..24650994,24651861..24652241,24652310..24652590,24652782..24653039,24653098..24653202); ID=FBpp0084040; name=ash2-PC; parent=FBgn0000139,FBtr0084660; dbxref=FlyBase:FBpp0084040,FlyBase_Annotation_IDs:CG6677-PC,GB_protein:AAO41602.1,REFSEQ:NP_788735,GB_protein:AAO41602,FlyMine:FBpp0084040,modMine:FBpp0084040; MD5=9a2a20a4332f4e530cc6d84f7e016cd9; length=556; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=3R:join(24650229..24650344,24650405..24650589,24650650..24650994,24651861..24652241,24652310..24652590,24652782..24653039,24653098..24653202); ID=FBpp0084040; name=ash2-PC; parent=FBgn0000139,FBtr0084660; dbxref=FlyBase:FBpp0084040,FlyBase_Annotation_IDs:CG6677-PC,GB_protein:AAO41602.1,REFSEQ:NP_788735,GB_protein:AAO41602,UniProt/Swiss-Prot:Q94545,FlyMine:FBpp0084040,modMine:FBpp0084040; MD5=9a2a20a4332f4e530cc6d84f7e016cd9; length=556; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 556 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA][ISS]
    Biological Process: imaginal disc-derived wing morphogenesis [IMP]
    imaginal disc-derived wing vein specification [IGI][IMP]
    chromatin-mediated maintenance of transcription [IMP]
    Molecular Function: zinc ion binding [IEA]
    protein binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEDSQMDTSS PTESSSEVNF TAEEDKSQET RSAAGVCYCG KERNLNIVEL LCATCSRWVH  60
   61 ETCVSYQLGK GKLLPFITNY VFVCKNCSAS GLESFRKSQA TISQMCHCAI ANMQQAASRD 120
  121 GRRQIQFSKD KEIIPYIEQY WEAMTTMPRR LTQSWYSTVQ RSLVKDVQTL FTYEEHAEHG 180
  181 AMYGLFHQDL RIIKPNYESM SKSGALRLTD DGYTQASLSK NNRQKRKFPG TDSGPTGKKG 240
  241 RPSSDITANV KLPPHGYPLE HPFNKDGYRY ILAEPDPHAP FRQEFDESSD WAGKPIPGWL 300
  301 YRILVPHSVL LALHDRAPQL KISEDRLAVT GERGYCMVRA THSVNRGCWY FEVTIEEMPD 360
  361 GAATRLGWGR EYGNLQAPLG YDKFGYSWRS RKGTKFTESH GKHYSDAYVE GDTLGFLIEL 420
  421 PEEASLDYLP NTFKDRPLVK FKSHLYYEDK DKITETLKNL HILQGSRIEF FKNGQSQGVA 480
  481 FEDIYAGSYF PAISIHKSAT VSVNFGPAFK YPEVLVEHKA KGMHDRVEEL ITEQCLADTL 540
  541 YLTEHDGRLR LDNMGL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..146] PSI-BLAST 8.69897 No description for 2f6jA was found.
    2 View Details [147..296] deduced N/A No confident structure predictions are available.
    3 View Details [297..556] PSI-BLAST 25.0 No description for 2fnjA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • binding
    		•  2.40096962515027 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.15398264148864 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.95513305822187 bayes_pls_golite062009
  • protein binding
    		•  1.80794638640093 bayes_pls_golite062009
  • DNA binding
    		•  1.80079581406991 bayes_pls_golite062009
  • transcription activator activity
    		•  1.26528137349343 bayes_pls_golite062009
  • transcription factor activity
    		•  1.15427978494805 bayes_pls_golite062009
  • structural molecule activity
    		•  0.591248843231149 bayes_pls_golite062009
  • protein kinase activity
    		•  0.349782201631236 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.256457488897892 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.145569571363938 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.0116447990963908 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle