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Protein Overview: ash2-PB

General Information:
Name(s) found: ash2-PB / FBpp0084039 [FlyBase]
Description(s) found:
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  • gi|40882417|gb|AAR96120.1| SD28012p [Drosophila melanogaster] [NCBI NR]
  • gi|24649737|ref|NP_733024.1| absent, small, or homeotic discs 2, isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|23172193|gb|AAN14010.1| absent, small, or homeotic discs 2, isoform B [Drosophila melanogaster] [NCBI NR]
  • The gene absent, small, or homeotic discs 2 is referred to in FlyBase by the symbol Dmel\ash2 (CG6677, FBgn0000139). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:20475769..20479099. It has the cytological map location 96A13. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: zinc ion binding; protein binding. There is experimental evidence that it is involved in the biological process</span>: imaginal disc-derived wing vein specification; chromatin-mediated maintenance of transcription; imaginal disc-derived wing morphogenesis. 28 alleles are reported. The phenotypes of these alleles are annotated with 17 unique terms, many of which group under: adult segment; organ system; thoracic segment; adult mesothoracic segment; appendage segment; adult metathoracic segment; imaginal precursor; adult; dorsal thoracic disc; multi-cell-component structure; antennal segment; mouthpart. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
  • >CG6677-PB translation from_gene[CG6677 ash2 FBgn0000139] seq_release:3 mol_weight=39745 cds_boundaries:(3R:20,467,982..20,469,578[+]) aa_length:350 transcript_info:[CG6677-RB seq_release:3] gene_info:[gene symbol:ash2 FBgn0000139 gene_boundaries:(3R:2 [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q8IMW1) CG6677-PB [DrosMelano7227.FASTAC.txt]
  • CG6677-PB, isoform B [Drosophila melanogaster]gi|24649737|ref|NP_733024.1| CG6677-PB [Drosophila melanogaster]gi|40882417|gb|AAR96120.1| SD28012p [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=3R:join(20477325..20477352,20477583..20477963,20478032..20478312,20478504..20478761,20478820..20478924); ID=FBpp0084039; name=ash2-PB; parent=FBgn0000139,FBtr0084659; dbxref=FlyBase:FBpp0084039,FlyBase_Annotation_IDs:CG6677-PB,GB_protein [fly-100309-contam.fasta]
  • SD28012p [Drosophila melanogaster] [nr-271106-contam.fasta]
  • absent, small, or homeotic discs 2 CG6677-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG6677-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=3R:join(20477325..20477352,20477583..20477963,20478032..20478312,20478504..20478761,20478820..20478924); ID=FBpp0084039; name=ash2-PB; parent=FBgn0000139,FBtr0084659; dbxref=FlyBase:FBpp0084039,FlyBase_Annotation_IDs:CG6677-PB,GB_protein:AAN14010.1,REFSEQ:NP_733024,GB_protein:AAN14010; MD5=c0f8213e6a30bd07a58ff5fc63598884; length=350; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3R:join(20477325..20477352,20477583..20477963,20478032..20478312,20478504..20478761,20478820..20478924); ID=FBpp0084039; name=ash2-PB; parent=FBgn0000139,FBtr0084659; dbxref=FlyBase:FBpp0084039,FlyBase_Annotation_IDs:CG6677-PB,GB_protein:AAN14010.1,REFSEQ:NP_733024,GB_protein:AAN14010; MD5=c0f8213e6a30bd07a58ff5fc63598884; length=350; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Absent, small, or homeotic discs 2, isoform B OS=Drosophila melanogaster GN=ash2 PE=2 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=3R:join(20477325..20477352,20477583..20477963,20478032..20478312,20478504..20478761,20478820..20478924); ID=FBpp0084039; name=ash2-PB; parent=FBgn0000139,FBtr0084659; dbxref=FlyBase:FBpp0084039,FlyBase_Annotation_IDs:CG6677-PB,GB_protein:AAN14010.1,REFSEQ:NP_733024,GB_protein:AAN14010,FlyMine:FBpp0084039,modMine:FBpp0084039; MD5=c0f8213e6a30bd07a58ff5fc63598884; length=350; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=3R:join(24651603..24651630,24651861..24652241,24652310..24652590,24652782..24653039,24653098..24653202); ID=FBpp0084039; name=ash2-PB; parent=FBgn0000139,FBtr0084659; dbxref=FlyBase:FBpp0084039,FlyBase_Annotation_IDs:CG6677-PB,GB_protein:AAN14010.1,REFSEQ:NP_733024,GB_protein:AAN14010,FlyMine:FBpp0084039,modMine:FBpp0084039; MD5=c0f8213e6a30bd07a58ff5fc63598884; length=350; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=3R:join(24651603..24651630,24651861..24652241,24652310..24652590,24652782..24653039,24653098..24653202); ID=FBpp0084039; name=ash2-PB; parent=FBgn0000139,FBtr0084659; dbxref=FlyBase:FBpp0084039,FlyBase_Annotation_IDs:CG6677-PB,GB_protein:AAN14010.1,REFSEQ:NP_733024,GB_protein:AAN14010,FlyMine:FBpp0084039,modMine:FBpp0084039; MD5=c0f8213e6a30bd07a58ff5fc63598884; length=350; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • Isoform of Q94545, Isoform B of Set1/Ash2 histone methyltransferase complex subunit ASH2 OS=Drosophila melanogaster GN=ash2 [DROME.fasta.20160308]
  • FBpp0084039 type=protein; loc=3R:join(24651603..24651630,24651861..24652241,24652310..24652590,24652782..24653039,24653098..24653202); ID=FBpp0084039; name=ash2-PB; parent=FBgn0000139,FBtr0084659; dbxref=FlyBase:FBpp0084039,FlyBase_Annotation_IDs:CG6677-PB,GB_protein:AAN14010.1,REFSEQ:NP_733024,GB_protein:AAN14010,FlyMine:FBpp0084039,modMine:FBpp0084039; MD5=c0f8213e6a30bd07a58ff5fc63598884; length=350; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=3R:join(24651603..24651630,24651861..24652241,24652310..24652590,24652782..24653039,24653098..24653202); ID=FBpp0084039; name=ash2-PB; parent=FBgn0000139,FBtr0084659; dbxref=FlyBase:FBpp0084039,FlyBase_Annotation_IDs:CG6677-PB,GB_protein:AAN14010.1,REFSEQ:NP_733024,GB_protein:AAN14010,FlyMine:FBpp0084039,modMine:FBpp0084039; MD5=c0f8213e6a30bd07a58ff5fc63598884; length=350; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 350 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA][ISS]
    Biological Process: imaginal disc-derived wing morphogenesis [IMP]
    imaginal disc-derived wing vein specification [IGI][IMP]
    chromatin-mediated maintenance of transcription [IMP]
    Molecular Function: zinc ion binding [IEA]
    protein binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASSFTDEES SLSKNNRQKR KFPGTDSGPT GKKGRPSSDI TANVKLPPHG YPLEHPFNKD  60
   61 GYRYILAEPD PHAPFRQEFD ESSDWAGKPI PGWLYRILVP HSVLLALHDR APQLKISEDR 120
  121 LAVTGERGYC MVRATHSVNR GCWYFEVTIE EMPDGAATRL GWGREYGNLQ APLGYDKFGY 180
  181 SWRSRKGTKF TESHGKHYSD AYVEGDTLGF LIELPEEASL DYLPNTFKDR PLVKFKSHLY 240
  241 YEDKDKITET LKNLHILQGS RIEFFKNGQS QGVAFEDIYA GSYFPAISIH KSATVSVNFG 300
  301 PAFKYPEVLV EHKAKGMHDR VEELITEQCL ADTLYLTEHD GRLRLDNMGL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..350] PSI-BLAST 32.39794 No description for 2fnjA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.40096962515027 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.15398264148864 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.95513305822187 bayes_pls_golite062009
  • protein binding
    		•  1.80794638640093 bayes_pls_golite062009
  • DNA binding
    		•  1.80079581406991 bayes_pls_golite062009
  • transcription activator activity
    		•  1.26528137349343 bayes_pls_golite062009
  • transcription factor activity
    		•  1.15427978494805 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle