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Protein Overview: PH4alphaSG2-PA

General Information:
Name(s) found: PH4alphaSG2-PA / FBpp0085015 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene prolyl-4-hydroxylase-alpha SG2 is referred to in FlyBase by the symbol Dmel\PH4Ã?&#142;Ã?±SG2 (CG1546, FBgn0039779). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:26315798..26317724. It has the cytological map location 99F6. Based on sequence similarity, it is predicted to have molecular function</span>: procollagen-proline 4-dioxygenase activity. There is experimental evidence that it is involved in the biological process</span>: salivary gland morphogenesis. 3 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 527 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum [IEA]
    procollagen-proline 4-dioxygenase complex [IC]
    Biological Process: oxidation reduction [IEA]
    salivary gland morphogenesis [IMP]
    Molecular Function: procollagen-proline 4-dioxygenase activity [ISS]
    L-ascorbic acid binding [IEA]
    oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [IEA]
    iron ion binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLDRHCLYIG IFQLIIWVGV ANGEFYSSVD SMQDLAQVEE ELLNATRSYV ESQQKQLDFY  60
   61 RRYVEQIKRE HEWATSQLKL DDYLGHPLHA FRLIKRLVRD WDSLIFEPIL ANNAREEFRA 120
  121 FVEVLSRDLG YPDQSELQGA IKGLARLQKV YNLATSDLAD GIIGGLNYGS DLRWRECYEI 180
  181 GVQLFDLGEY QRSLEWLQVA FILLRNSPRE EKDADHYLSD IREYASMANF ELGNPKKAAR 240
  241 LLSQILESQP THSAQQTQKY LESRVPGKNV QETKPSWFSN YTRLCQGRRL PEERSGDPLR 300
  301 CYLDGKRHAY FTLAPLQVEP VHLDPDINVY HGMLSSKQIL SIFEEADKEE MVRSAVAGSG 360
  361 GEGTVRDLRV SQQTWLDYKS PVMNSVGRII QFVSGFDMAG AEHMQVANYG VGGQYEPHPD 420
  421 YFEVNLPKNF EGDRISTSMF YLSDVEQGGY TVFTKLNVFL PPVKGALVMW HNLHRSLHVD 480
  481 ARTLHAGCPV IVGSKRIGNI WMHSGYQEFR RPCNLTSDSY KSLAYRD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..171] Pfam 61.065502 No description for PF08336.2 was found. No confident structure predictions are available.
    2 View Details [172..275] PSI-BLAST 17.522879 Crystal structure of peptide-substrate-binding domain of human type I collagen prolyl 4-hydroxylase
    3 View Details [276..527] PSI-BLAST 22.522879 No description for 2g19A was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • procollagen-proline 4-dioxygenase activity
    		•  7.0422525853653 bayes_pls_golite062009
  • procollagen-proline dioxygenase activity
    		•  7.0422525853653 bayes_pls_golite062009
  • peptidyl-proline dioxygenase activity
    		•  7.0422525853653 bayes_pls_golite062009
  • peptidyl-proline 4-dioxygenase activity
    		•  7.0422525853653 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
    		•  5.01373106146099 bayes_pls_golite062009
  • binding
    		•  2.09193012129784 bayes_pls_golite062009
  • protein binding
    		•  1.52807685989528 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH, with oxygen as acceptor
    		•  0.534990536504941 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.41

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle