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Protein Overview: shf-PA

General Information:
Name(s) found: shf-PA / FBpp0070939 [FlyBase]
Description(s) found:
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  • gi|61217438|sp|Q9W3W5.2|WIF1_DROME RecName: Full=Protein shifted; AltName: Full=WIF-1-like protein; Flags: Precursor [NCBI NR]
  • gi|22831848|gb|AAF46198.2| shifted [Drosophila melanogaster] [NCBI NR]
  • gi|18858113|ref|NP_572349.1| shifted [Drosophila melanogaster] [NCBI NR]
  • gi|15291555|gb|AAK93046.1| GH27042p [Drosophila melanogaster] [NCBI NR]
  • Protein shifted OS=Drosophila melanogaster GN=shf PE=1 SV=2 [Swiss-Prot]
  • The gene shifted is referred to in FlyBase by the symbol Dmel\shf (CG3135, FBgn0003390). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:6665477..6673692. It has the cytological map location 6C13-6D1. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: smoothened signaling pathway; regulation of smoothened signaling pathway; protein stabilization; Wnt receptor signaling pathway. 20 alleles are reported. The phenotypes of these alleles are annotated with 15 unique terms, many of which group under: adult segment; adult mesothoracic segment; organ system; peripheral nervous system; nervous system; external compound sense organ; thoracic segment; wing cell; compound cell cluster organ; integumentary plate. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • >CG3135-PA translation from_gene[CG3135 CG3135 FBgn0029901] seq_release:3 mol_weight=50742 cds_boundaries:(X:6,511,995..6,515,327[-]) aa_length:456 transcript_info:[CG3135-RA seq_release:3] gene_info:[gene symbol:CG3135 FBgn0029901 gene_boundaries:(X:6 [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9W3W5) CG3135 protein (GH27042p) [DrosMelano7227.FASTAC.txt]
  • CG3135-PA [Drosophila melanogaster]gi|15291555|gb|AAK93046.1| GH27042p [Drosophila melanogaster]gi|18858113|ref|NP_572349.1| CG3135-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=X:complement(6665649..6665692,6665770..6665967,6666038..6666133,6667094..6667282,6667948..6668142,6668216..6668473,6668594..6668984); ID=FBpp0070939; name=shf-PA; parent=FBgn0003390,FBtr0070978; dbxref=FlyBase:FBpp0070939,FlyBase_Annotat [fly-100309-contam.fasta]
  • CG3135-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • GH27042p [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Protein shifted precursor (WIF-1-like protein) [nr-271106-contam.fasta]
  • shifted CG3135-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=X:complement(6665649..6665692,6665770..6665967,6666038..6666133,6667094..6667282,6667948..6668142,6668216..6668473,6668594..6668984); ID=FBpp0070939; name=shf-PA; parent=FBgn0003390,FBtr0070978; dbxref=FlyBase:FBpp0070939,FlyBase_Annotation_IDs:CG3135-PA,GB_protein:AAF46198.2,REFSEQ:NP_572349,GB_protein:AAF46198; MD5=cd683023ffb39e8048b626df9abe951f; length=456; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=X:complement(6665649..6665692,6665770..6665967,6666038..6666133,6667094..6667282,6667948..6668142,6668216..6668473,6668594..6668984); ID=FBpp0070939; name=shf-PA; parent=FBgn0003390,FBtr0070978; dbxref=FlyBase:FBpp0070939,FlyBase_Annotation_IDs:CG3135-PA,GB_protein:AAF46198.2,REFSEQ:NP_572349,GB_protein:AAF46198; MD5=cd683023ffb39e8048b626df9abe951f; length=456; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • type=protein; loc=X:complement(6665649..6665692,6665770..6665967,6666038..6666133,6667094..6667282,6667948..6668142,6668216..6668473,6668594..6668984); ID=FBpp0070939; name=shf-PA; parent=FBgn0003390,FBtr0070978; dbxref=FlyBase:FBpp0070939,FlyBase_Annotation_IDs:CG3135-PA,GB_protein:AAF46198.2,REFSEQ:NP_572349,GB_protein:AAF46198,FlyMine:FBpp0070939,modMine:FBpp0070939; MD5=cd683023ffb39e8048b626df9abe951f; length=456; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=X:complement(join(6774561..6774951,6774183..6774440,6773915..6774109,6773061..6773249,6772005..6772100,6771737..6771934,6771616..6771659)); ID=FBpp0070939; name=shf-PA; parent=FBgn0003390,FBtr0070978; dbxref=FlyBase:FBpp0070939,FlyBase_Annotation_IDs:CG3135-PA,GB_protein:AAF46198.2,REFSEQ:NP_572349,GB_protein:AAF46198,FlyMine:FBpp0070939,modMine:FBpp0070939; MD5=cd683023ffb39e8048b626df9abe951f; length=456; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=X:complement(join(6774561..6774951,6774183..6774440,6773915..6774109,6773061..6773249,6772005..6772100,6771737..6771934,6771616..6771659)); ID=FBpp0070939; name=shf-PA; parent=FBgn0003390,FBtr0070978; dbxref=FlyBase:FBpp0070939,FlyBase_Annotation_IDs:CG3135-PA,GB_protein:AAF46198.2,REFSEQ:NP_572349,GB_protein:AAF46198,FlyMine:FBpp0070939,modMine:FBpp0070939; MD5=cd683023ffb39e8048b626df9abe951f; length=456; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • FBpp0070939 type=protein; loc=X:complement(join(6774561..6774951,6774183..6774440,6773915..6774109,6773061..6773249,6772005..6772100,6771737..6771934,6771616..6771659)); ID=FBpp0070939; name=shf-PA; parent=FBgn0003390,FBtr0070978; dbxref=FlyBase:FBpp0070939,FlyBase_Annotation_IDs:CG3135-PA,GB_protein:AAF46198.2,REFSEQ:NP_572349,GB_protein:AAF46198,FlyMine:FBpp0070939,modMine:FBpp0070939; MD5=cd683023ffb39e8048b626df9abe951f; length=456; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=X:complement(join(6774561..6774951,6774183..6774440,6773915..6774109,6773061..6773249,6772005..6772100,6771737..6771934,6771616..6771659)); ID=FBpp0070939; name=shf-PA; parent=FBgn0003390,FBtr0070978; dbxref=FlyBase:FBpp0070939,FlyBase_Annotation_IDs:CG3135-PA,GB_protein:AAF46198.2,REFSEQ:NP_572349,GB_protein:AAF46198,UniProt/Swiss-Prot:Q9W3W5,FlyMine:FBpp0070939,modMine:FBpp0070939; MD5=cd683023ffb39e8048b626df9abe951f; length=456; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 456 amino acids

    Gene Ontology:
    Cellular Component: extracellular region [IDA]
    proteinaceous extracellular matrix [IDA]
    Biological Process: smoothened signaling pathway [IGI][IMP]
    Wnt receptor signaling pathway [IMP]
    protein stabilization [IMP]
    regulation of smoothened signaling pathway [IMP]
    Molecular Function: protein tyrosine kinase activity [IEA]
    protein binding [IPI]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTHQGIGCLV KWLYLVLIVH TLLCIGQLEC RQQHHNRNNN NNNRRADSSS SEEGHGNTSD  60
   61 GLDNFADQDA SFVGHGHQPR RGQRKKQQGG GGGGSGGGGG NGGGGGSRHN RNEESGISLW 120
  121 INEQQLKMLT ALYFPQGYSE RLYAIHNSRV TNDLRDTTLY NFLVIPSEVN YVNFTWKSGR 180
  181 RKYFYDFDRL QTMDESILKA PTLSIRKSGR IPQEQKNFSI FLPCTGNSSG TASFNVGLKI 240
  241 QTRHNKPLSG TPIRLNFKKE CAHRGVYDID ASNPTSLTTL QECSLKCGKN GYCNEHHICK 300
  301 CNVGYTGQYC ETAFCFPQCL NGGNCTAPSV CTCPEGYQGT QCEGGICKDK CLNGGKCIQK 360
  361 DKCQCSKGYY GLRCEYSKCV IPCKNEGRCI GNNLCRCPNG LRGDHCEIGR KQRSICKCRN 420
  421 GTCVSHKHCK CHPGFYGRHC NGRKRRHVHR NDDSKF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..100] deduced N/A No confident structure predictions are available.
    2 View Details [101..162] PSI-BLAST 15.0 No description for 2d3jA was found.
    3 View Details [163..456] PSI-BLAST 11.39794 Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains; Ligand-binding domain of low-density lipoprotein receptor

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • receptor binding
    		•  4.60755835611133 bayes_pls_golite062009
  • growth factor activity
    		•  3.72526290796901 bayes_pls_golite062009
  • binding
    		•  2.07793256968292 bayes_pls_golite062009
  • protein binding
    		•  1.71989387545809 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  1.68731507829717 bayes_pls_golite062009
  • heparin binding
    		•  1.47717701519646 bayes_pls_golite062009
  • epidermal growth factor receptor binding
    		•  1.25957748598741 bayes_pls_golite062009
  • transcription factor binding
    		•  0.697310246671849 bayes_pls_golite062009
  • ErbB-3 class receptor binding
    		•  0.65339109098708 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.566933146071483 bayes_pls_golite062009
  • polysaccharide binding
    		•  0.50776094968211 bayes_pls_golite062009
  • ErbB-2 class receptor binding
    		•  0.470263535896705 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.396984935987962 bayes_pls_golite062009
  • pattern binding
    		•  0.365394105720783 bayes_pls_golite062009
  • structural molecule activity
    		•  0.076107837006494 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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