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Protein Overview: rpc2

General Information:
Name(s) found: rpc2 / SPAC4G9.08c [Sanger Pombe]
Description(s) found:
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  • gi|76782167|gb|ABA54854.1| RNA polymerase III large subunit Rpc2 [Schizosaccharomyces pombe] [NCBI NR]
  • pir||T38867 probable DNA-directed RNA polymerase III 130 kd subunit - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • gi|19114602|ref|NP_593690.1| DNA-directed RNA polymerase III complex subunit Rpc2 [Schizosaccharomyces pombe] [NCBI NR]
  • gi|1710663|sp|Q10233.1|RPC2_SCHPO RecName: Full=DNA-directed RNA polymerase III subunit RPC2; Short=RNA polymerase III subunit C2; Short=RNA polymerase III subunit 2; AltName: Full=DNA-directed RNA polymerase III 130 kDa polypeptide; AltName: Full=RPC130; [NCBI NR]
  • gi|1204209|emb|CAA93558.1| DNA-directed RNA polymerase III complex subunit Rpc2 [Schizosaccharomyces pombe] [NCBI NR]
  • DNA-directed RNA polymerase III complex subunit Rpc2 [Sanger Pombe]
  • DNA-directed RNA polymerase III subunit RPC2 OS=Schizosaccharomyces pombe GN=rpc2 PE=2 SV=1 [Swiss-Prot]
  • DNA-DIRECTED RNA POLYMERASE III 130 KD SUBUNIT: Q10233; [pompepVF.fasta]
  • DNA-DIRECTED RNA POLYMERASE III 130 KD POLYPEPTIDE: Q10233; [pompepV13]
  • Putative DNA-directed RNA polymerase III 130 kDa polypeptide (EC 2.7.7.6) (RNA polymerase III subunit 2) [pompep4896]
  • |rpc2||DNA-directed RNA polymerase III 130 kD subunit [pompepnew.fasta]
  • |rpc2||localization DNA-directed RNA polymerase III complex (subunit)|Schizosaccharomyces pombe|chr 1|||Manual [pombe041504.fasta]
  • putative dna-directed rna polymerase iii 130 kd polypeptide (ec 2.7.7.6) [Schizosaccharomyces pombe]gi|1204209|emb|CAA93558.1| SPAC4G9.08c [Schizosaccharomyces pombe]gi|1710663|sp|Q10233|RPC2_SCHPO Putative DNA-directed RNA polymerase III 130 kDa polype [nrdb_11152004_Chlamydomonas]
  • |rpc2||localization DNA-directed RNA polymerase III complex |Schizosaccharomyces pombe|chr 1|||Manual [pompep2242005.fasta]
  • (Q10233) Putative DNA-directed RNA polymerase III 130 kDa polypeptide (EC 2.7.7.6) (RNA polymerase III subunit 2) [pompep4896_normal_reversed]
  • |rpc2||DNA-directed RNA polymerase III complex subunit Rpc2|Schizosaccharomyces pombe|chr 1|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • SPAC4G9.08c [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • RNA polymerase III large subunit Rpc2 [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • hypothetical protein SPAC4G9.08c [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • Putative DNA-directed RNA polymerase III 130 kDa polypeptide (RNA polymerase III subunit 2) [nr-271106-contam.fasta]
  • DNA-directed RNA polymerase III subunit RPC2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=rpc2 PE=2 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 1165 amino acids

    Gene Ontology:
    Cellular Component: cytosol [IDALink to PubMed article]
    DNA-directed RNA polymerase III complex [NASLink to PubMed article]
    Biological Process: transcription from RNA polymerase III promoter [NASLink to PubMed article]
    Molecular Function: DNA binding [IEA]
    zinc ion binding [IEA]
    DNA-directed RNA polymerase activity [NASLink to PubMed article]
    ribonucleoside binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGVNTAGDPQ KSQPKINKGG IGKDESFGAL FKPVYKGKKL ADPVPTIEDK WQLLPAFLKV  60
   61 KGLVKQHLDS YNYFVDVDLK KIVQANEKVT SDVEPWFYLK YLDIRVGAPV RTDADAIQAS 120
  121 ISPHECRLRD LTYGANIYVD IEYTRGKQVV RRRNVPIGRM PVMLRSNKCV LSGKNEMEMA 180
  181 ALNECPLDPG GYFIVKGTEK VILVQEQLSK NRIIVEAEPK KGLWQASVTS STHERKSKTY 240
  241 VITKNGKLYL KHNSVADDIP IVVVLKAMGL QSDQEIFELV AGAEASYQDL FAPSIEECAK 300
  301 LNIYTAQQAL EYIGARVKVN RRAGANRLPP HEEALEVLAA VVLAHINVFN LEFRPKAVYI 360
  361 GIMARRVLMA MVDPLQVDDR DYVGNKRLEL AGQLLALLFE DLFKKFNSDL KLNIDKVLKK 420
  421 PHRTQEFDAY NQLTVHSDHI TQGMVRALST GNWSLKRFKM ERAGVTHVLS RLSYISALGM 480
  481 MTRITSQFEK TRKVSGPRSL QASQFGMLCT SDTPEGEACG LVKNLALMTH ITTDEEEEPI 540
  541 IKLAYAFGIE DIHVISGREL HSHGTYLVYL NGAILGISRY PSLFVASFRK LRRSGKISPF 600
  601 IGIFINTHQR AVFISTDGGR ICRPLIIVQN GLPKVESKHI RLLKEGKWGF EDFLKQGLVE 660
  661 YVDVNEENDS LISVYERDIT PDTTHLEIEP FTILGAVAGL IPYPHHNQSP RNTYQCAMGK 720
  721 QAIGAIAYNQ LQRIDTLLYL MVYPQQPMVK TKTIELIGYD KLPAGQNATV AIMSYSGYDI 780
  781 EDALVLNKSS IDRGFGRCQV FHKHSVIVRK YPNGTHDRIG DPQRDPETGE VVWKHGVVED 840
  841 DGLAGVGCRV QPGQIYVNKQ TPTNALDNSI TLGHTQTVES GYKATPMTYK APEPGYIDKV 900
  901 MLTTTDSDQT LIKVLMRQTR RPELGDKFSS RHGQKGVCGV IVQQEDMPFN DQGICPDIIM 960
  961 NPHGFPSRMT VGKMIELLSG KVGVLRGTLE YGTCFGGTKV EDASRILVEH GYNYSGKDML1020
 1021 TSGITGETLE AYIFMGPIYY QKLKHMVMDK MHARARGPRA VLTRQPTEGR SRDGGLRLGE1080
 1081 MERDCLIAYG ASQLLLERLM ISSDACDVDV CGQCGLLGYK GWCNSCQSTR EVVKMTIPYA1140
 1141 AKLLFQELLS MNIVPRLALE DEFKY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..1165] PSI-BLAST 1000.0 RBP2

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA-directed RNA polymerase activity
    		•  10.2021663255698 bayes_pls_golite062009
  • RNA polymerase activity
    		•  10.2021663255698 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  7.6240729546188 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  6.31198922553685 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  5.44374972993429 bayes_pls_golite062009
  • transferase activity
    		•  4.83218811360621 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.34884279395902 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.33174616086951 bayes_pls_golite062009
  • DNA binding
    		•  2.27079409864244 bayes_pls_golite062009
  • binding
    		•  1.73416306650822 bayes_pls_golite062009
  • RNA polymerase II transcription mediator activity
    		•  1.53259746846673 bayes_pls_golite062009
  • catalytic activity
    		•  1.36406839864424 bayes_pls_golite062009
  • RNA binding
    		•  1.12618950637766 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.847783043631028 bayes_pls_golite062009
  • protein binding
    		•  0.45174975126993 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle