Protein Overview: TRP1

General Information:
Name(s) found:	TRP1 / YDR007W [SGD]
Description(s) found: Found 34 descriptions. SHOW ALL	Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA) [SGD]
Organism:	Saccharomyces cerevisiae
Length:	224 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [TAS]
Biological Process:	tryptophan biosynthetic process [IDA][IMP][TAS] cellular amino acid metabolic process [TAS]
Molecular Function:	phosphoribosylanthranilate isomerase activity [IDA][IMP]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVINFTGSS GPLVKVCGLQ STEAAECALD SDADLLGIIC VPNRKRTIDP VIARKISSLV  60
   61 KAYKNSSGTP KYLVGVFRNQ PKEDVLALVN DYGIDIVQLH GDESWQEYQE FLGLPVIKRL 120
  121 VFPKDCNILL SAASQKPHSF IPLFDSEAGG TGELLDWNSI SDWVGRQESP ESLHFMLAGG 180
  181 LTPENVGDAL RLNGVIGVDV SGGVETNGVK DSNKIANFVK NAKK

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	ARF2	TRP1	2	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	TRP1	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..224]	PSI-BLAST	57.69897	N-(5'phosphoribosyl)antranilate isomerase, PRAI

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
tryptophan synthase activity	2.99898167480072	bayes_pls_golite062009
indole-3-glycerol-phosphate synthase activity	2.98379231184807	bayes_pls_golite062009
phosphoribosylanthranilate isomerase activity	2.57188946638955	bayes_pls_golite062009
catalytic activity	2.44231061702877	bayes_pls_golite062009
carbon-carbon lyase activity	1.80077901589281	bayes_pls_golite062009
carboxy-lyase activity	1.32677036501434	bayes_pls_golite062009
imidazoleglycerol-phosphate synthase activity	0.567370625225674	bayes_pls_golite062009
lyase activity	0.258652421339738	bayes_pls_golite062009

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.79

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2