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Protein Overview: METB_ECOLI

General Information:
Name(s) found: METB_ECOLI [Swiss-Prot]
Description(s) found:
Found 10 descriptions.
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  • Cystathionine gamma-synthase (EC 2.5.1.48) (CGS) (O-succinylhomoserine (thiol)-lyase) - Escherichia coli [Swiss-Prot]
    • Organism: Escherichia coli
    Length: 386 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTRKQATIAV RSGLNDDEQY GCVVPPIHLS STYNFTGFNE PRAHDYSRRG NPTRDVVQRA  60
   61 LAELEGGAGA VLTNTGMSAI HLVTTVFLKP GDLLVAPHDC YGGSYRLFDS LAKRGCYRVL 120
  121 FVDQGDEQAL RAALAEKPKL VLVESPSNPL LRVVDIAKIC HLAREVGAVS VVDNTFLSPA 180
  181 LQNPLALGAD LVLHSCTKYL NGHSDVVAGV VIAKDPDVVT ELAWWANNIG VTGGAFDSYL 240
  241 LLRGLRTLVP RMELAQRNAQ AIVKYLQTQP LVKKLYHPSL PENQGHEIAA RQQKGFGAML 300
  301 SFELDGDEQT LRRFLGGLSL FTLAESLGGV ESLISHAATM THAGMAPEAR AAAGISETLL 360
  361 RISTGIEDGE DLIADLENGF RAANKG

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..386] PSI-BLAST 99.0 Cystathionine gamma-synthase, CGS

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor
    		•  2.82824364293374 bayes_pls_golite062009
  • glycine dehydrogenase (decarboxylating) activity
    		•  2.82824364293374 bayes_pls_golite062009
  • catalytic activity
    		•  2.29878871754893 bayes_pls_golite062009
  • L-aspartate:2-oxoglutarate aminotransferase activity
    		•  1.87460342369605 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.67701710033155 bayes_pls_golite062009
  • DNA binding
    		•  1.4774443071095 bayes_pls_golite062009
  • transferase activity
    		•  1.44093490824786 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.39741122443159 bayes_pls_golite062009
  • transferase activity, transferring nitrogenous groups
    		•  1.28316822767388 bayes_pls_golite062009
  • transaminase activity
    		•  1.24990480711889 bayes_pls_golite062009
  • transcription factor activity
    		•  1.15775909410582 bayes_pls_golite062009
  • binding
    		•  1.09053123792737 bayes_pls_golite062009
  • O-phospho-L-serine:2-oxoglutarate aminotransferase activity
    		•  0.994935084630764 bayes_pls_golite062009
  • ligase activity
    		•  0.827063849687833 bayes_pls_golite062009
  • carbon-sulfur lyase activity
    		•  0.698312655247044 bayes_pls_golite062009
  • cystathionine beta-lyase activity
    		•  0.6849039330512 bayes_pls_golite062009
  • vitamin binding
    		•  0.66463470119531 bayes_pls_golite062009
  • cystathionine gamma-lyase activity
    		•  0.505859361763689 bayes_pls_golite062009
  • alanine-glyoxylate transaminase activity
    		•  0.48682493494502 bayes_pls_golite062009
  • O-acyltransferase activity
    		•  0.452440867878365 bayes_pls_golite062009
  • cysteine synthase activity
    		•  0.417849187928985 bayes_pls_golite062009
  • structural molecule activity
    		•  0.347975812448725 bayes_pls_golite062009
  • glycine hydroxymethyltransferase activity
    		•  0.271623203801431 bayes_pls_golite062009
  • pyridoxal phosphate binding
    		•  0.16957228630576 bayes_pls_golite062009
  • vitamin B6 binding
    		•  0.16957228630576 bayes_pls_golite062009
  • adenosylmethionine-8-amino-7-oxononanoate transaminase activity
    		•  0.0669652799570574 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.90

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle