YRC Public Data Repository - Protein Structure Prediction

Protein:	YL455_YEAST
Organism:	Saccharomyces cerevisiae S288c
Length:	304 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YL455_YEAST.

Description	E-value	Query Range	Subject Range
YLR455W - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to th... YL455_YEAST - PWWP domain-containing protein YLR455W OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=Y...	4.0E-79	[1..304]	[1..304]
SPBC29A3.13 - PWWP domain protein PDP1_SCHPO - PWWP domain-containing protein 1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=pdp1 PE=1...	5.0E-60	[5..290]	[50..350]
gi\|5823166, gi\|2... - gi\|5823166\|gb\|AAD53062.1\|AF156487_1 DNA cytosine-5 methyltransferase 3 beta 3 [Homo sapiens], gi\|574...	5.0E-39	[3..222]	[221..452]
GLYR1_MOUSE - Putative oxidoreductase GLYR1 OS=Mus musculus GN=Glyr1 PE=1 SV=1	1.0E-38	[4..198]	[5..178]

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Predicted Domain #1

Region A:
Residues: [1-83]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTKDIRTGDL VLCKVGSFPP WPAVVFPQRL LRNDVYRKRK SNCVAVCFFN DPTYYWEQPS  60
   61 RLKELDQDSI HNFILEHSKN ANQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	22.045757
Match:	1khcA_
Description:	DNA methyltransferase DNMT3B
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	2.4854263045204	bayes_pls_golite062009
protein binding	1.51678357126614	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [84-145]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RELVNAYKEA KNFDDFNVFL QEKFEEENRL SDLKAFEKSE GSKIVAGEDP FVGRTKVVNK  60
   61 RK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	22.045757
Match:	1khcA_
Description:	DNA methyltransferase DNMT3B
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [146-242]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KNSISIKEDP EDNQKSNEEE SKPNIKPSKK KRPTANSGGK SNSGNKKKVK LDYSRRVEIS  60
   61 QLFRRRIQRN LIQRETPPTE HEIKETHELL NRIYENS

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4

Region A:
Residues: [243-304]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DTKRPFFDLK ALRESKLHKL LKAIVNDPDL GEFHPLCKEI LLSWADLITE LKKEKLQALP  60
   61 TP

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.689	0.966	nucleus	a.4.1	Homeodomain-like

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: