YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|16760134
Organism:	Salmonella enterica subsp. enterica serovar Typhi str. CT18
Length:	892 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|16760134.

Description	E-value	Query Range	Subject Range
gi\|62127947, gi\|... - gi\|62180314\|ref\|YP_216731.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Salmonella enteric...	0.0	[1..892]	[1..892]
gi\|197248827, gi... - gi\|197248827\|ref\|YP_002146279.1\| aldehyde-alcohol dehydrogenase [Salmonella enterica subsp. enterica... gi\|197264457, gi... - gi\|197264457\|ref\|ZP_03164531.1\| aldehyde-alcohol dehydrogenase [Salmonella enterica subsp. enterica ... gi\|194472562, gi... - gi\|194472562\|ref\|ZP_03078546.1\| aldehyde-alcohol dehydrogenase [Salmonella enterica subsp. enterica ... lcl\|NC_016856.1_... - [gene=adhE] [protein=bifunctional acetaldehyde-CoA/alcohol dehydrogenase] [protein_id=YP_005237675.1... gi\|194713283, gi... - gi\|194737781\|ref\|YP_002114780.1\| aldehyde-alcohol dehydrogenase [Salmonella enterica subsp. enterica... gi\|16420280, gi\|... - gi\|16765093\|ref\|NP_460708.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Salmonella typhimu... gi\|194445482, gi... - gi\|194445482\|ref\|YP_002041001.1\| aldehyde-alcohol dehydrogenase [Salmonella enterica subsp. enterica... gi\|194449103, gi... - gi\|194449103\|ref\|YP_002045794.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Salmonella ent... gi\|205351103, gi... - gi\|205351103\|gb\|EDZ37734.1\| aldehyde-alcohol dehydrogenase [Salmonella enterica subsp. enterica sero... gi\|205343856, gi... - gi\|205343856\|gb\|EDZ30620.1\| aldehyde-alcohol dehydrogenase [Salmonella enterica subsp. enterica sero... gi\|168237803, gi... - gi\|197289287\|gb\|EDY28654.1\| aldehyde-alcohol dehydrogenase [Salmonella enterica subsp. enterica sero... gi\|168241329, gi... - gi\|205339532\|gb\|EDZ26296.1\| aldehyde-alcohol dehydrogenase [Salmonella enterica subsp. enterica sero... gi\|205327523, gi... - gi\|205327523\|gb\|EDZ14287.1\| aldehyde-alcohol dehydrogenase [Salmonella enterica subsp. enterica sero... gi\|205335357, gi... - gi\|205335357\|gb\|EDZ22121.1\| aldehyde-alcohol dehydrogenase [Salmonella enterica subsp. enterica sero... gi\|205321926, gi... - gi\|205321926\|gb\|EDZ09765.1\| aldehyde-alcohol dehydrogenase [Salmonella enterica subsp. enterica sero... gi\|56413327, gi\|... - gi\|56413327\|ref\|YP_150402.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Salmonella enteric... gi\|207856741, gi... - gi\|207856741\|ref\|YP_002243392.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Salmonella ent... gi\|224583759, gi... - gi\|224583759\|ref\|YP_002637557.1\| alcohol dehydrogenase [Salmonella enterica subsp. enterica serovar ... gi\|200390520, gi... - gi\|200390520\|ref\|ZP_03217131.1\| aldehyde-alcohol dehydrogenase [Salmonella enterica subsp. enterica ... gi\|205272361, gi... - gi\|205352580\|ref\|YP_002226381.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Salmonella ent... gi\|197362252, gi... - gi\|197362252\|ref\|YP_002141889.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Salmonella ent... gi\|198244315, gi... - gi\|198244315\|ref\|YP_002215394.1\| aldehyde-alcohol dehydrogenase [Salmonella enterica subsp. enterica...	0.0	[1..879]	[1..879]
gi\|36785819, gi\|... - gi\|37526388\|ref\|NP_929732.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Photorhabdus lumin...	0.0	[8..876]	[8..875]
gi\|229702148, gi... - gi\|229894855\|ref\|ZP_04510034.1\| multifunctional acetaldehyde-CoA dehydrogenase and iron-dependent al... gi\|45441777, gi\|... - gi\|45441777\|ref\|NP_993316.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Yersinia pestis bi... gi\|25283753 - pir\|\|AG0265 alcohol dehydrogenase (EC 1.1.1.1) [imported] - Yersinia pestis (strain CO92) gi\|15980182, gi\|... - gi\|218929278\|ref\|YP_002347153.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Yersinia pesti... gi\|51596429, gi\|... - gi\|51596429\|ref\|YP_070620.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Yersinia pseudotub... gi\|167400929, gi... - gi\|167400929\|ref\|ZP_02306435.1\| aldehyde-alcohol dehydrogenase [Yersinia pestis biovar Antiqua str. ... gi\|166961867, gi... - gi\|167420172\|ref\|ZP_02311925.1\| aldehyde-alcohol dehydrogenase [Yersinia pestis biovar Orientalis st... gi\|170024307, gi... - gi\|170024307\|ref\|YP_001720812.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Yersinia pseud... gi\|186698503, gi... - gi\|186895477\|ref\|YP_001872589.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Yersinia pseud... gi\|165938272, gi... - gi\|89104991\|ref\|ZP_01177519.1\| COG1012: NAD-dependent aldehyde dehydrogenases [Yersinia pestis biova... gi\|108807532, gi... - gi\|108807532\|ref\|YP_651448.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Yersinia pestis A... gi\|162351931, gi... - gi\|77634014\|ref\|ZP_00796124.1\| COG1012: NAD-dependent aldehyde dehydrogenases [Yersinia pestis Angol... gi\|153949366, gi... - gi\|77629185\|ref\|ZP_00791771.1\| COG1012: NAD-dependent aldehyde dehydrogenases [Yersinia pseudotuberc... gi\|149292312, gi... - gi\|149365899\|ref\|ZP_01887934.1\| aldehyde-alcohol dehydrogenase [Yersinia pestis CA88-4125], gi\|14929... gi\|145209949, gi... - gi\|145598253\|ref\|YP_001162329.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Yersinia pesti... gi\|165927374, gi... - gi\|165927374\|ref\|ZP_02223206.1\| aldehyde-alcohol dehydrogenase [Yersinia pestis biovar Orientalis st... gi\|165991833, gi... - gi\|166009278\|ref\|ZP_02230176.1\| aldehyde-alcohol dehydrogenase [Yersinia pestis biovar Antiqua str. ... gi\|166207689, gi... - gi\|166210509\|ref\|ZP_02236544.1\| aldehyde-alcohol dehydrogenase [Yersinia pestis biovar Antiqua str. ... Q66AM7\|Q66AM7_YERPS - Aldehyde-alcohol dehydrogenase - Yersinia pseudotuberculosis gi\|229688536, gi... - gi\|229898246\|ref\|ZP_04513393.1\| multifunctional acetaldehyde-CoA dehydrogenase and iron-dependent al... gi\|229897601, gi... - gi\|229897601\|ref\|ZP_04512757.1\| multifunctional acetaldehyde-CoA dehydrogenase and iron-dependent al...	0.0	[1..890]	[1..891]
gi\|229681001, gi... - gi\|229902105\|ref\|ZP_04517226.1\| multifunctional acetaldehyde-CoA dehydrogenase and iron-dependent al... gi\|167424931, gi... - gi\|167424931\|ref\|ZP_02316684.1\| aldehyde-alcohol dehydrogenase [Yersinia pestis biovar Mediaevalis s... gi\|22125915, gi\|... - gi\|22125915\|ref\|NP_669338.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Yersinia pestis KI...	0.0	[1..890]	[1..891]
gi\|75190291, gi\|... - gi\|75190291\|ref\|ZP_00703558.1\| COG1012: NAD-dependent aldehyde dehydrogenases [Escherichia coli E243...	0.0	[1..872]	[1..872]
gi\|91210463, gi\|... - gi\|91210463\|ref\|YP_540449.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Escherichia coli U... gi\|110641469, gi... - gi\|110641469\|ref\|YP_669199.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Escherichia coli ... gi\|191171097, gi... - gi\|75242041\|ref\|ZP_00725835.1\| COG1012: NAD-dependent aldehyde dehydrogenases [Escherichia coli F11]... gi\|218558168, gi... - gi\|218558168\|ref\|YP_002391081.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Escherichia co... gi\|227836535, gi... - gi\|227886331\|ref\|ZP_04004136.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Escherichia col... gi\|218426749, gi... - gi\|218689185\|ref\|YP_002397397.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Escherichia co... gi\|237705204, gi... - gi\|237705204\|ref\|ZP_04535685.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Escherichia sp.... gi\|117623455, gi... - gi\|117623455\|ref\|YP_852368.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Escherichia coli ...	0.0	[1..872]	[1..872]
gi\|209397364, gi... - gi\|209397364\|ref\|YP_002270171.1\| aldehyde-alcohol dehydrogenase [Escherichia coli O157:H7 str. EC411... gi\|209911739, gi... - gi\|209918480\|ref\|YP_002292564.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Escherichia co... gi\|217328522, gi... - gi\|217328522\|ref\|ZP_03444604.1\| aldehyde-alcohol dehydrogenase [Escherichia coli O157:H7 str. TW1458... gi\|218553791, gi... - gi\|218553791\|ref\|YP_002386704.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Escherichia co... gi\|218351487, gi... - gi\|218694755\|ref\|YP_002402422.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Escherichia co... ADHE_ECOLI - Aldehyde-alcohol dehydrogenase [Includes: Alcohol dehydrogenase (EC 1.1.1.1) (ADH); Acetaldehyde deh... gi\|218704762, gi... - gi\|218704762\|ref\|YP_002412281.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Escherichia co... ADHE_ECO57 - Aldehyde-alcohol dehydrogenase OS=Escherichia coli O157:H7 GN=adhE PE=3 SV=2 EG10031 - fused acetaldehyde-CoA dehydrogenase /iron-dependent alcohol dehydrogenase /pyruvate-formate lyase dea... gi\|169755323, gi... - gi\|170020395\|ref\|YP_001725349.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Escherichia co... gi\|170080868, gi... - gi\|170080868\|ref\|YP_001730188.1\| fused acetaldehyde-CoA dehydrogenase and iron-dependent alcohol deh... gi\|170521664, gi... - gi\|170683946\|ref\|YP_001743955.1\| aldehyde-alcohol dehydrogenase [Escherichia coli SMS-3-5], gi\|17052... gi\|188488280, gi... - gi\|188493081\|ref\|ZP_03000351.1\| alcohol dehydrogenase, iron-containing family [Escherichia coli 5363... gi\|195939126 - gi\|195939126\|ref\|ZP_03084508.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Escherichia col... gi\|208727064, gi... - gi\|208807263\|ref\|ZP_03249600.1\| aldehyde-alcohol dehydrogenase [Escherichia coli O157:H7 str. EC4206... gi\|208814825, gi... - gi\|208814825\|ref\|ZP_03256004.1\| aldehyde-alcohol dehydrogenase [Escherichia coli O157:H7 str. EC4045... gi\|208822680, gi... - gi\|208822680\|ref\|ZP_03262999.1\| aldehyde-alcohol dehydrogenase [Escherichia coli O157:H7 str. EC4042... gi\|238861164, gi... - gi\|238900472\|ref\|YP_002926268.1\| fused acetaldehyde-CoA dehydrogenase/iron-dependent alcohol dehydro... gi\|251784745, gi... - gi\|251784745\|ref\|YP_002999049.1\| hypothetical protein B21_01225 [Escherichia coli BL21], gi\|24237701... gi\|253324807, gi... - gi\|254288128\|ref\|YP_003053876.1\| fused acetaldehyde-CoA dehydrogenase/iron-dependent alcohol dehydro... gi\|253973221, gi... - gi\|254161320\|ref\|YP_003044428.1\| fused acetaldehyde-CoA dehydrogenase/iron-dependent alcohol dehydro... gi\|254592109, gi... - gi\|254792709\|ref\|YP_003077546.1\| multifunctional acetaldehyde-CoA dehydrogenase and iron-dependent a... gi\|192927569, gi... - gi\|75257144\|ref\|ZP_00728680.1\| COG1012: NAD-dependent aldehyde dehydrogenases [Escherichia coli E22]... gi\|193069981, gi... - gi\|75235251\|ref\|ZP_00719488.1\| COG1012: NAD-dependent aldehyde dehydrogenases [Escherichia coli E110... gi\|191166635, gi... - gi\|75230201\|ref\|ZP_00716702.1\| COG1012: NAD-dependent aldehyde dehydrogenases [Escherichia coli B7A]... gi\|75212672, gi\|... - gi\|75212672\|ref\|ZP_00712670.1\| COG1012: NAD-dependent aldehyde dehydrogenases [Escherichia coli B171... gi\|82776584, gi\|... - gi\|82776584\|ref\|YP_402933.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Shigella dysenteri... gi\|74312423, gi\|... - gi\|74312423\|ref\|YP_310842.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Shigella sonnei Ss... gi\|124500610, gi... - gi\|124528378\|ref\|ZP_01699688.1\| iron-containing alcohol dehydrogenase [Escherichia coli B], gi\|12450... EG10031 - fused acetaldehyde-CoA dehydrogenase /iron-dependent alcohol dehydrogenase /pyruvate-formate lyase dea... gi\|157160746, gi... - gi\|75195390\|ref\|ZP_00705460.1\| COG1012: NAD-dependent aldehyde dehydrogenases [Escherichia coli HS],... gi\|187732417, gi... - gi\|75179164\|ref\|ZP_00699182.1\| COG1012: NAD-dependent aldehyde dehydrogenases [Shigella boydii BS512... gi\|194437153, gi... - gi\|83587379\|ref\|ZP_00926007.1\| COG1012: NAD-dependent aldehyde dehydrogenases [Escherichia coli 101-... gi\|188015070, gi... - gi\|188015070\|gb\|EDU53192.1\| aldehyde-alcohol dehydrogenase [Escherichia coli O157:H7 str. EC4113], g... gi\|168758165, gi... - gi\|189354993\|gb\|EDU73412.1\| aldehyde-alcohol dehydrogenase [Escherichia coli O157:H7 str. EC4401], g... gi\|189365623, gi... - gi\|189365623\|gb\|EDU84039.1\| aldehyde-alcohol dehydrogenase [Escherichia coli O157:H7 str. EC4501], g... gi\|168771129, gi... - gi\|189360050\|gb\|EDU78469.1\| aldehyde-alcohol dehydrogenase [Escherichia coli O157:H7 str. EC4486], g... gi\|89108085, gi\|... - gi\|89108085\|ref\|AP_001865.1\| fused acetaldehyde-CoA dehydrogenase and iron-dependent alcohol dehydro... gi\|168776868, gi... - gi\|187767785\|gb\|EDU31629.1\| aldehyde-alcohol dehydrogenase [Escherichia coli O157:H7 str. EC4196], g... gi\|13361206, gi\|... - gi\|15830995\|ref\|NP_309768.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Escherichia coli O... gi\|168784151, gi... - gi\|188998619\|gb\|EDU67605.1\| aldehyde-alcohol dehydrogenase [Escherichia coli O157:H7 str. EC4076], g... gi\|168787744, gi... - gi\|189372491\|gb\|EDU90907.1\| aldehyde-alcohol dehydrogenase [Escherichia coli O157:H7 str. EC869], gi... gi\|189376312, gi... - gi\|189376312\|gb\|EDU94728.1\| aldehyde-alcohol dehydrogenase [Escherichia coli O157:H7 str. EC508], gi...	0.0	[1..872]	[1..872]
gi\|82544308, gi\|... - gi\|82544308\|ref\|YP_408255.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Shigella boydii Sb...	0.0	[1..872]	[1..872]
gi\|25283746 - gi\|25283746\|pir\|\|D85704 hypothetical protein adhE [imported] - Escherichia coli (strain O157:H7, su... gi\|12514960, gi\|... - gi\|15801467\|ref\|NP_287484.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Escherichia coli O...	0.0	[1..872]	[1..872]

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Predicted Domain #1

Region A:
Residues: [1-447]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAVTNVAELN ALVERVKKAQ REYASFTQEQ VDKIFRAAAL AAADARIPLA KMAVAESGMG  60
   61 IVEDKVIKNH FASEYIYNAY KDEKTCGVLS EDDTFGTITI AEPIGIICGI VPTTNPTSTA 120
  121 IFKSLISLKT RNAIIFSPHP RAKEATNKAA DIVLQAAIAA GAPKDLIGWI DQPSVELSNA 180
  181 LMHHPDINLI LATGGPGMVK AAYSSGKPAI GVGAGNTPVV IDETADIKRA VASVLMSKTF 240
  241 DNGVICASEQ SVVVVDSVYD AVRERFASHG GYMLQGQELK AVQNVILKNG ALNAAIVGQP 300
  301 AYKIAELAGF SVPETTKILI GEVTVVDESE PFAHEKLSPT LAMYRAKDFE EAVEKAEKLV 360
  361 AMGGIGHTSC LYTDQDNQPE RVAYFGQMMK TARILINTPA SQGGIGDLYN FKLAPSLTLG 420
  421 CGSWGGNSIS ENVGPKHLIN KKTVAKR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	136.0
Match:	1bxsA
Description:	Aldehyde reductase (dehydrogenase), ALDH
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
oxidoreductase activity	4.47226217021998	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	4.34495776828926	bayes_pls_golite062009
3-chloroallyl aldehyde dehydrogenase activity	3.37049090049734	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	3.2867555127991	bayes_pls_golite062009
aldehyde dehydrogenase (NAD) activity	2.81851373615334	bayes_pls_golite062009
catalytic activity	2.80804701752928	bayes_pls_golite062009
benzaldehyde dehydrogenase activity	1.80313175632526	bayes_pls_golite062009
methylmalonate-semialdehyde dehydrogenase (acylating) activity	1.59279206536309	bayes_pls_golite062009
1-pyrroline-5-carboxylate dehydrogenase activity	1.15620590715864	bayes_pls_golite062009
binding	0.637403449596354	bayes_pls_golite062009
NAD or NADH binding	0.00649065522387682	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [448-892]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AENMLWHKLP KSIYFRRGSL PIALDEVITD GHKRALIVTD RFLFNNGYAD QITSVLKAAG  60
   61 VETEVFFEVE ADPTLSVVRK GAELANSFKP DVIIALGGGS PMDAAKIMWV MYEHPETHFE 120
  121 ELALRFMDIR KRIYKFPKMG VKAKMIAVTT TSGTGSEVTP FAVVTDNATG QKYPLADYAL 180
  181 TPDMAIVDAN LVMDMPKSLC AFGGLDAVTH ALEAYVSVLA SEFSDGQALQ ALKLLKENLP 240
  241 ASYHEGSKNP VARERVHSAA TIAGIAFANA FLGVCHSMAH KLGSQFHIPH GLANALLICN 300
  301 VIRYNANDNP TKQTAFSQYD RPQARRRYAE IADHLGLSAP GDRTAAKIEK LLAWLESIKA 360
  361 ELGIPKSIRE AGVQEADFLA HVDKLSEDAF DDQCTGANPR YPLISELKQI LLDTYYGRDF 420
  421 TEGEVAAKKD VVAAPKAEKK AKKSA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	100.0
Match:	1rrmA
Description:	Crystal Structure of Lactaldehyde reductase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
alcohol dehydrogenase (NAD) activity	5.26400058766942	bayes_pls_golite062009
oxidoreductase activity	3.07409531087588	bayes_pls_golite062009
alcohol dehydrogenase activity, metal ion-independent	3.05722501802075	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	2.83823088483915	bayes_pls_golite062009
catalytic activity	2.37357608468991	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	2.10085302216488	bayes_pls_golite062009
binding	1.15096180564234	bayes_pls_golite062009
3-chloroallyl aldehyde dehydrogenase activity	0.831155115586418	bayes_pls_golite062009
cation binding	0.319000821544479	bayes_pls_golite062009
metal ion binding	0.319000821544479	bayes_pls_golite062009
ion binding	0.313606245452103	bayes_pls_golite062009
protein binding	0.295023706645045	bayes_pls_golite062009
transition metal ion binding	0.259889634539407	bayes_pls_golite062009
hydroxyacid-oxoacid transhydrogenase activity	0.146499147589879	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	0.0904828025133766	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: