YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|16760609
Organism:	Salmonella enterica subsp. enterica serovar Typhi str. CT18
Length:	644 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|16760609.

Description	E-value	Query Range	Subject Range
gi\|62127500, gi\|... - gi\|62179867\|ref\|YP_216284.1\| hypothetical protein SC1297 [Salmonella enterica subsp. enterica serova... gi\|224584208, gi... - gi\|224584208\|ref\|YP_002638006.1\| hypothetical protein SPC_2456 [Salmonella enterica subsp. enterica ...	0.0	[1..644]	[11..654]
gi\|28897761, gi\|... - gi\|28897761\|ref\|NP_797366.1\| hypothetical protein VP0988 [Vibrio parahaemolyticus RIMD 2210633], gi\|... gi\|149749355, gi... - gi\|153837324\|ref\|ZP_01989991.1\| PrkA AAA [Vibrio parahaemolyticus AQ3810], gi\|149749355\|gb\|EDM60128.... gi\|28805974 - gi\|28805974\|dbj\|BAC59250.1\| conserved hypothetical protein [Vibrio parahaemolyticus RIMD 2210633]	0.0	[1..644]	[1..644]
gi\|194539923, gi... - gi\|75856409\|ref\|ZP_00764038.1\| COG2766: Putative Ser protein kinase [Vibrio sp. Ex25], gi\|254229010\|...	0.0	[1..644]	[20..663]
gi\|204927511, gi... - gi\|204927511\|ref\|ZP_03218712.1\| serine protein kinase, PrkA [Salmonella enterica subsp. enterica ser... gi\|207857214, gi... - gi\|207857214\|ref\|YP_002243865.1\| putative serine kinase [Salmonella enterica subsp. enterica serovar... gi\|198245623, gi... - gi\|198245623\|ref\|YP_002215850.1\| serine protein kinase, PrkA [Salmonella enterica subsp. enterica se... gi\|199602229, gi... - gi\|200389784\|ref\|ZP_03216395.1\| serine protein kinase, PrkA [Salmonella enterica subsp. enterica ser... gi\|197247484, gi... - gi\|197247484\|ref\|YP_002146754.1\| serine protein kinase, PrkA [Salmonella enterica subsp. enterica se... gi\|197242819, gi... - gi\|197264564\|ref\|ZP_03164638.1\| serine protein kinase, PrkA [Salmonella enterica subsp. enterica ser... gi\|194468848, gi... - gi\|194468848\|ref\|ZP_03074832.1\| serine protein kinase, PrkA [Salmonella enterica subsp. enterica ser... gi\|194712239, gi... - gi\|194736737\|ref\|YP_002114302.1\| serine protein kinase, PrkA [Salmonella enterica subsp. enterica se... gi\|194403963, gi... - gi\|194445300\|ref\|YP_002040542.1\| serine protein kinase, PrkA [Salmonella enterica subsp. enterica se... gi\|194451442, gi... - gi\|194451442\|ref\|YP_002045291.1\| serine protein kinase, PrkA [Salmonella enterica subsp. enterica se... gi\|238910898 - gi\|238910898\|ref\|ZP_04654735.1\| putative serine kinase [Salmonella enterica subsp. enterica serovar ... gi\|168264177, gi... - gi\|205347248\|gb\|EDZ33879.1\| serine protein kinase, PrkA [Salmonella enterica subsp. enterica serovar... gi\|168463324, gi... - gi\|195634237\|gb\|EDX52589.1\| serine protein kinase, PrkA [Salmonella enterica subsp. enterica serovar... gi\|16419801, gi\|... - gi\|16764636\|ref\|NP_460251.1\| putative serine protein kinase [Salmonella typhimurium LT2], gi\|1641980... gi\|197288271, gi... - gi\|197288271\|gb\|EDY27656.1\| PrkA AAA domain protein [Salmonella enterica subsp. enterica serovar Sch... gi\|205336740, gi... - gi\|205336740\|gb\|EDZ23504.1\| serine protein kinase, PrkA [Salmonella enterica subsp. enterica serovar... gi\|167991904, gi... - gi\|205329684\|gb\|EDZ16448.1\| serine protein kinase, PrkA [Salmonella enterica subsp. enterica serovar... gi\|205332604, gi... - gi\|205332604\|gb\|EDZ19368.1\| serine protein kinase, PrkA [Salmonella enterica subsp. enterica serovar... lcl\|NC_016856.1_... - [gene=yeaG] [protein=putative serine protein kinase] [protein_id=YP_005237133.1] [location=complemen... gi\|161614316, gi... - gi\|161614316\|ref\|YP_001588281.1\| hypothetical protein SPAB_02062 [Salmonella enterica subsp. enteric... gi\|205322982, gi... - gi\|205322982\|gb\|EDZ10821.1\| serine protein kinase, PrkA [Salmonella enterica subsp. enterica serovar...	0.0	[1..644]	[1..644]
gi\|91225257, gi\|... - gi\|91225257\|ref\|ZP_01260425.1\| hypothetical protein V12G01_20858 [Vibrio alginolyticus 12G01], gi\|91...	0.0	[1..644]	[1..644]
gi\|189355044, gi... - gi\|189355044\|gb\|EDU73463.1\| serine kinase family protein [Escherichia coli O157:H7 str. EC4401], gi\|... gi\|115513077, gi... - gi\|117623953\|ref\|YP_852866.1\| hypothetical protein APECO1_851 [Escherichia coli APEC O1], gi\|1155130... gi\|188016301, gi... - gi\|188016301\|gb\|EDU54423.1\| serine kinase family protein [Escherichia coli O157:H7 str. EC4113], gi\|... gi\|124498125, gi... - gi\|124532174\|ref\|ZP_01702137.1\| putative serine protein kinase, PrkA [Escherichia coli B], gi\|124498... gi\|189360389, gi... - gi\|189360389\|gb\|EDU78808.1\| serine kinase family protein [Escherichia coli O157:H7 str. EC4486], gi\|... gi\|189365718, gi... - gi\|189365718\|gb\|EDU84134.1\| serine kinase family protein [Escherichia coli O157:H7 str. EC4501], gi\|... gi\|208730868, gi... - gi\|208816525\|ref\|ZP_03257645.1\| serine kinase family protein [Escherichia coli O157:H7 str. EC4045],... gi\|208810742, gi... - gi\|208810742\|ref\|ZP_03252618.1\| serine kinase family protein [Escherichia coli O157:H7 str. EC4206],... gi\|209919145, gi... - gi\|209919145\|ref\|YP_002293229.1\| hypothetical protein ECSE_1954 [Escherichia coli SE11], gi\|20991240... gi\|209398535, gi... - gi\|209398535\|ref\|YP_002270858.1\| serine kinase family protein [Escherichia coli O157:H7 str. EC4115]... gi\|217318117, gi... - gi\|217328770\|ref\|ZP_03444851.1\| serine kinase family protein [Escherichia coli O157:H7 str. TW14588]... gi\|215486999, gi... - gi\|215486999\|ref\|YP_002329430.1\| conserved protein with nucleoside triphosphate hydrolase domain [Es... gi\|218365420, gi... - gi\|218558651\|ref\|YP_002391564.1\| conserved hypothetical protein; putative nucleoside triphosphate hy... gi\|218554351, gi... - gi\|218554351\|ref\|YP_002387264.1\| conserved hypothetical protein; putative nucleoside triphosphate hy... gi\|168782211, gi... - gi\|189000272\|gb\|EDU69258.1\| serine kinase family protein [Escherichia coli O157:H7 str. EC4076], gi\|... gi\|187769477, gi... - gi\|187769477\|gb\|EDU33321.1\| serine kinase family protein [Escherichia coli O157:H7 str. EC4196], gi\|... gi\|189376741, gi... - gi\|189376741\|gb\|EDU95157.1\| serine kinase family protein [Escherichia coli O157:H7 str. EC508], gi\|1... gi\|168788192, gi... - gi\|189371935\|gb\|EDU90351.1\| serine kinase family protein [Escherichia coli O157:H7 str. EC869], gi\|1... gi\|170081439, gi... - gi\|170081439\|ref\|YP_001730759.1\| hypothetical protein ECDH10B_1921 [Escherichia coli str. K-12 subst... gi\|169754799, gi... - gi\|170019871\|ref\|YP_001724825.1\| putative serine protein kinase, PrkA [Escherichia coli ATCC 8739], ... gi\|195937471 - gi\|195937471\|ref\|ZP_03082853.1\| hypothetical protein EscherichcoliO157_13647 [Escherichia coli O157:... gi\|170684310, gi... - gi\|170684310\|ref\|YP_001743466.1\| serine kinase family protein [Escherichia coli SMS-3-5], gi\|1705220... EG13493 - protein kinase, endogenous substrate unidentified; autokinase / Protein kinase, function unknown; au... YEAG_ECOLI - Hypothetical protein yeaG - Escherichia coli gi\|89108622, gi\|... - gi\|89108622\|ref\|AP_002402.1\| conserved hypothetical protein with nucleoside triphosphate hydrolase d... gi\|91211000, gi\|... - gi\|91211000\|ref\|YP_540986.1\| hypothetical protein UTI89_C1979 [Escherichia coli UTI89], gi\|91072574\|... gi\|15831746, gi\|... - gi\|15831746\|ref\|NP_310519.1\| hypothetical protein ECs2492 [Escherichia coli O157:H7 str. Sakai], gi\|... gi\|110641905, gi... - gi\|110641905\|ref\|YP_669635.1\| hypothetical protein ECP_1731 [Escherichia coli 536], gi\|110343497\|gb\|... YEAG_ECOL6 - Uncharacterized protein YeaG OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) GN=yeaG ... EG13493 - protein kinase, endogenous substrate unidentified; autokinase / Protein kinase, function unknown; au... YEAG_ECO57 - Uncharacterized protein YeaG OS=Escherichia coli O157:H7 GN=yeaG PE=3 SV=1 YEAG_ECOL6 - Uncharacterized protein yeaG OS=Escherichia coli O6 GN=yeaG PE=3 SV=1 gi\|12515817, gi\|... - gi\|15802197\|ref\|NP_288219.1\| hypothetical protein Z2823 [Escherichia coli O157:H7 EDL933], gi\|125158... gi\|75190814, gi\|... - gi\|75190814\|ref\|ZP_00704081.1\| COG2766: Putative Ser protein kinase [Escherichia coli E24377A], gi\|1... gi\|75195851, gi\|... - gi\|75195851\|ref\|ZP_00705921.1\| COG2766: Putative Ser protein kinase [Escherichia coli HS], gi\|157161... gi\|191168998, gi... - gi\|75227732\|ref\|ZP_00714464.1\| COG2766: Putative Ser protein kinase [Escherichia coli B7A], gi\|19116... gi\|193068879, gi... - gi\|75236750\|ref\|ZP_00720821.1\| COG2766: Putative Ser protein kinase [Escherichia coli E110019], gi\|1... gi\|75241342, gi\|... - gi\|75241342\|ref\|ZP_00725193.1\| COG2766: Putative Ser protein kinase [Escherichia coli F11], gi\|19117... gi\|193066592, gi... - gi\|75255304\|ref\|ZP_00727137.1\| COG2766: Putative Ser protein kinase [Escherichia coli E22], gi\|19306... gi\|188487999, gi... - gi\|75513719\|ref\|ZP_00736095.1\| COG2766: Putative Ser protein kinase [Escherichia coli 53638], gi\|188... gi\|82543818, gi\|... - gi\|82543818\|ref\|YP_407765.1\| hypothetical protein SBO_1310 [Shigella boydii Sb227], gi\|81245229\|gb\|A... gi\|218695342, gi... - gi\|218695342\|ref\|YP_002403009.1\| conserved hypothetical protein; putative nucleoside triphosphate hy... gi\|218689724, gi... - gi\|218689724\|ref\|YP_002397936.1\| conserved hypothetical protein; putative nucleoside triphosphate hy... gi\|218432378, gi... - gi\|218705281\|ref\|YP_002412800.1\| conserved hypothetical protein; putative nucleoside triphosphate hy... gi\|218699649, gi... - gi\|218699649\|ref\|YP_002407278.1\| conserved hypothetical protein; putative nucleoside triphosphate hy... gi\|227885788, gi... - gi\|227885788\|ref\|ZP_04003593.1\| inner spore coat serine protein kinase [Escherichia coli 83972], gi\|... gi\|226900492, gi... - gi\|237705735\|ref\|ZP_04536216.1\| serine kinase [Escherichia sp. 3_2_53FAA], gi\|226900492\|gb\|EEH86751.... gi\|238900997, gi... - gi\|238900997\|ref\|YP_002926793.1\| hypothetical protein BWG_1596 [Escherichia coli BW2952], gi\|2388606... gi\|254793405, gi... - gi\|254793405\|ref\|YP_003078242.1\| conserved protein with nucleoside triphosphate hydrolase domain [Es...	0.0	[1..644]	[1..644]
gi\|194428508, gi... - gi\|75210260\|ref\|ZP_00710428.1\| COG2766: Putative Ser protein kinase [Escherichia coli B171], gi\|1944...	0.0	[1..644]	[1..644]
gi\|73855383, gi\|... - gi\|74311906\|ref\|YP_310325.1\| hypothetical protein SSON_1379 [Shigella sonnei Ss046], gi\|73855383\|gb\|...	0.0	[1..644]	[1..644]
gi\|194421428, gi... - gi\|83584969\|ref\|ZP_00923624.1\| COG2766: Putative Ser protein kinase [Escherichia coli 101-1], gi\|194...	0.0	[1..644]	[1..644]
gi\|83569609, gi\|... - gi\|83569609\|ref\|ZP_00921060.1\| COG2766: Putative Ser protein kinase [Shigella dysenteriae 1012], gi\|...	0.0	[1..644]	[1..644]

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Predicted Domain #1

Region A:
Residues: [1-411]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNIFDHYRQR YEAAKDEEFT LQDFLTICRQ DRSAYANAAE RLLMAIGEPN MVDTAQEPRL  60
   61 SRLFSNRVIA RYPAFEEFYG MEDAIEQIVS YLKHAAQGLE EKKQILYLLG PVGGGKSSLA 120
  121 ERLKSLMQRV PIYVLSANGE RSPVNDHPLC LFNPQEDAQI LEKEYGIPRR YLGTIMSPWA 180
  181 AKHLHEFGGD ITKFRVVKVW PSILEQIAIA KTEPGDENNQ DISALVGKVD IRKLEHHAQN 240
  241 DPDAYGYSGA LCRANQGIME FVEMFKAPIK VLPPLLTATQ EGNYNGTEGI SALPFNGIIL 300
  301 AHSNESEWVT FRNNKNNEAF LDRVYIVKVP YCLRISEEIK IYEKLLNHSE LAHAPCAPGT 360
  361 LETLSRFSTL SRLKEPENSS IYSKMRVYDG ESLKDTDPKA KSYQEYRDYA G

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	45.522879
Match:	1ny5A
Description:	Crystal structure of sigm54 activator (AAA+ ATPase) in the inactive state
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
purine ribonucleotide binding	1.77188881592277	bayes_pls_golite062009
ribonucleotide binding	1.7716739686218	bayes_pls_golite062009
purine nucleotide binding	1.7592051236943	bayes_pls_golite062009
nucleotide binding	1.7500232772987	bayes_pls_golite062009
ATP binding	1.47995731296981	bayes_pls_golite062009
adenyl ribonucleotide binding	1.44574285885277	bayes_pls_golite062009
two-component response regulator activity	1.42213431254922	bayes_pls_golite062009
adenyl nucleotide binding	1.41874021678514	bayes_pls_golite062009
binding	1.15116915808666	bayes_pls_golite062009
kinase activity	1.07775443369837	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.896897432710546	bayes_pls_golite062009
protein kinase activity	0.756932393503009	bayes_pls_golite062009
hydrolase activity	0.502565068825558	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.447655793851911	bayes_pls_golite062009
transferase activity	0.168270793917772	bayes_pls_golite062009
protein serine/threonine kinase activity	0.120699179262929	bayes_pls_golite062009
protein binding	0.0523017713981208	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [412-474]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VDEGMNGLST RFAFKILSRV FNFDHAEVAA NPVHLFYVLE QQIEREQFPQ EQAERYLEFL  60
   61 KGY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	51.69897
Match:	1ojlA
Description:	Crystal structure of a sigma54-activator suggests the mechanism for the conformational switch necessary for sigma54 binding
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [475-644]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LIPKYAEFIG KEIQTAYLES YSEYGQNIFD RYVTYADFWI QDQEYRDPDT GQLFDRESLN  60
   61 AELEKIEKPA GISNPKDFRN EIVNFVLRAR ANNSGRNPNW TSYEKLRTVI EKKMFSNTEE 120
  121 LLPVISFNAK TSTDEQKKHD DFVDRMMEKG YTRKQVRLLC EWYLRVRKSS

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	72.251812
Match:	PF06798.3
Description:	No description for PF06798.3 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: